1.
Chem Commun (Camb)
; 57(92): 12329-12332, 2021 Nov 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34740232
RESUMO
Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.