Assuntos
Antioxidantes/química , Alcaloides Indólicos/química , Monoterpenos/química , Rubiaceae/química , Antioxidantes/isolamento & purificação , Antioxidantes/farmacologia , Cristalografia por Raios X , Alcaloides Indólicos/isolamento & purificação , Alcaloides Indólicos/farmacologia , Modelos Moleculares , Estrutura Molecular , Monofenol Mono-Oxigenase/antagonistas & inibidores , Monoterpenos/isolamento & purificação , Monoterpenos/farmacologia , Casca de Planta/química , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologiaRESUMO
The title compound, C30H44O5, is a penta-cyclic triterpene isolated from the Cameroonian medicinal plant Nauclea Pobeguinii and known as quafrinoic acid. The mol-ecule is composed of five fused six-membered rings, four of which adopt a chair conformation and one a half-chair conformation. Intra-molecular C-Hâ¯O hydrogen-bond inter-actions exist, which generate S6 and S8 rings. In the crystal, mol-ecules are linked by pairs of O-Hâ¯O hydrogen bonds, linking R22(8) rings into chains running parallel to the a axis; these chains are further connected into layers parallel to the ab plane by C-Hâ¯O hydrogen bonds. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from Hâ¯H (79.4%) and Oâ¯H (20.4%) inter-actions.
