Evaluation of Serum Immunoglobulins (IgG, IgA, IgM) and Circulating Immune Complexes in Oral Precancer and Cancer Patients.

Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG, and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and precancer patients. Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins, and CIC was estimated by turbidometry and ELISA method. Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ± 118.02) mg/dL, oral cancers were 270.67 ( ± 171.44) mg/dL, and controls were 133.73 ( ± 101.31) mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ± 316) mg/dL, oral cancers were 1,234.27 ( ± 365.42) mg/dL, and controls were 593.87 ( ± 323.06) mg/dL. Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer and cancer group, and Serum IgM levels were increased only in precancer. Also, significant increase in serum CIC levels were seen in oral precancer and cancer group on comparison with control.

Evaluation of stress in three different fiber posts with two-dimensional finite element analysis.

INTRODUCTION: The primary function of corono-radicular post is to provide retention for the core and to reinforce and to replace the remaining coronal tooth structure. There is considerable controversy regarding optimal choice of the material. An ideal post system should exhibit fracture resistance higher than the average masticatory forces. Finite elemental analysis (FEA) method facilitates precise analysis of the distribution and magnitude of stresses at any point of complex and irregular structures. Thus, this FEA study has been undertaken to evaluate the fracture stress distribution patterns in three fiber posts, viz., carbon, glass fiber, and everStick with an FEA. MATERIALS AND METHODS: The FE stress analysis was performed with the FE software program (CATIA). Three two-dimensional FEA models of central incisor were simulated, and elastic moduli and Poisson's ratio of all the materials were fed to the software. For all the models, a 200 N vertical force was applied on the lingual surface of the tooth at an angle of 45°. Stress concentration and distribution were evaluated and noted down for all the models. To evaluate the stresses within the restored tooth, the modified von Mises failure criterion was used. The equivalent stresses found in the tested models were compared with the tensile strength of the respective materials. Contact stresses in the luting cement-dentin interface were calculated. RESULTS: Finite element method revealed that maximum stress concentration was at the point of stress application. The stress value was highest in carbon fiber post followed by glass fiber post and least stresses found in everStick post. Maximum stress was observed at the labial surfaces of crown. However, the stress values and distribution were more homogenous in everStick post. CONCLUSION: The present findings suggest that everStick post has uniform stress distribution within tooth structure.

Eosinophilic Granuloma Presenting as Palatal Swelling.

Swellings involving palate can be challenging to diagnose for the clinician as they have wide range of origin which can result from developmental, inflammatory, reactive or a neoplastic process. The clinical presentation of these swellings is similar and difficult to differentiate from each other. So it is important to take proper history from the patient and subject the patient to appropriate laboratory and radiographic investigations and finally biopsy is mandatory for accurate diagnosis. Thus, this article highlights on various common palatal swellings, their clinical presentation, and differential diagnosis helpful for proper diagnosis of swellings associated with palate.