The reprogramming therapy for a patient with advanced hepatocellular carcinoma by using human-induced pluripotent stem (iPS) cells technology.

Therapeutic methods to reprogramme and destroy human solid tumour cells have not been developed. We show a proof-of-concept for the direct reprogramming therapy of human solid tumour cells. Furthermore, our study is the first to report on the development of a new treatment by using human-induced pluripotent stem cells technology.

Stable expressions of nine genes within human oocytes and live birth by in vitro fertilisation.

The development of new methods to cryopreserve human ovarian cortex tissues without damage is needed for the improvement of quality of life of female cancer patients. Here, we show that stable expressions of nine genes within human oocytes by using a supercooling procedure are necessary in order to produce human mature eggs and experience live births with high safety profiles by in vitro fertilisation. Our method will be helpful in order to preserve the fertility of female cancer patients or healthy women.