RESUMO
Aging leads to central artery stiffening and associated hemodynamic sequelae. Because healthy arteries exhibit differential geometry, composition, and mechanical behaviors along the central vasculature, we sought to determine whether wall structure and mechanical function differ across five vascular regions-the ascending and descending thoracic aorta, suprarenal and infrarenal abdominal aorta, and common carotid artery-in 20 versus 100-week-old male wild-type mice. Notwithstanding generally consistent changes across these regions, including a marked thickening of the arterial wall, diminished in vivo axial stretch, and loss of elastic energy storage capacity, the degree of changes tended to be slightly greater in abdominal than in thoracic or carotid vessels. Likely due to the long half-life of vascular elastin, most mechanical changes in the arterial wall resulted largely from a distributed increase in collagen, including thicker fibers in the media, and localized increases in glycosaminoglycans. Changes within the central arteries associated with significant increases in central pulse pressure and adverse changes in the left ventricle, including increased cardiac mass and decreased diastolic function. Given the similar half-life of vascular elastin in mice and humans but very different life-spans, there are important differences in the aging of central vessels across these species. Nevertheless, the common finding of aberrant matrix remodeling contributing to a compromised mechanical homeostasis suggests that studies of central artery aging in the mouse can provide insight into mechanisms and treatment strategies for the many adverse effects of vascular aging in humans.
Assuntos
Envelhecimento , Doenças Cardiovasculares/fisiopatologia , Homeostase , Animais , Aorta Abdominal/fisiopatologia , Aorta Torácica/fisiopatologia , Fenômenos Biomecânicos , Sistema Cardiovascular , Artérias Carótidas/fisiopatologia , Artéria Carótida Primitiva/fisiopatologia , Diástole , Modelos Animais de Doenças , Elastina/fisiologia , Proteínas da Matriz Extracelular/genética , Hemodinâmica , Humanos , Masculino , Camundongos , Modelos Cardiovasculares , Pressão , Proteínas Recombinantes/genética , Estresse Mecânico , Fatores de Tempo , Rigidez VascularRESUMO
An adolescent with long-standing HIV infection who was severely immunosuppressed during HIV diagnosis developed cholangiocarcinoma 1.5 years after starting antiretroviral therapy.
