RESUMO
We report these cases to emphasize the importance of recognizing fluoroscopy as a cause of radiation dermatitis. The diagnosis of fluoroscopy-induced chronic radiation dermatitis should be raised when patients present with morpheaform, telangiectatic, or ulcerative skin findings in the characteristic locations.
Assuntos
Fluoroscopia/efeitos adversos , Radiodermite/etiologia , Idoso , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiodermite/patologiaAssuntos
Adenocarcinoma Mucinoso/patologia , Neoplasias Faciais/patologia , Neoplasias Cutâneas/patologia , Adenocarcinoma Mucinoso/cirurgia , Idoso de 80 Anos ou mais , Biópsia por Agulha , Neoplasias Faciais/cirurgia , Seguimentos , Humanos , Imuno-Histoquímica , Masculino , Estadiamento de Neoplasias , Neoplasias Cutâneas/cirurgia , Transplante de Pele/métodos , Resultado do TratamentoRESUMO
Nocardia, Actinomyces, and Streptomyces species comprise the three broad classes of organisms that are causative for bacterial mycetoma. Although culture and molecular laboratory studies can usually identify the precise etiologic agent in bacterial mycetoma, occasionally these methods fail to clarify this situation. We report a classic clinical case of this infectious disease where usual diagnostic methods failed to identify the responsible organism, and discuss the empiric approach to such cases.
Assuntos
Micetoma/diagnóstico , Nocardia/isolamento & purificação , Pele/microbiologia , Antibacterianos/uso terapêutico , Emigrantes e Imigrantes , Reações Falso-Negativas , Antebraço/microbiologia , Antebraço/patologia , Humanos , Masculino , Técnicas Microbiológicas , Pessoa de Meia-Idade , Micetoma/tratamento farmacológico , Micetoma/microbiologia , Pele/patologia , Combinação Trimetoprima e Sulfametoxazol/uso terapêuticoRESUMO
Few papers discuss the potential challenge of differentiating dermatophytosis from subacute cutaneous lupus erythematosus. This masquerade, most often manifest on the face, is of both clinical and therapeutic importance. We report a patient whose extensive tinea corporis very closely mimicked SCLE. The threshold for biopsy should be low in cases that exhibit atypical features for either of these entities.
Assuntos
Lúpus Eritematoso Cutâneo/diagnóstico , Pele/patologia , Tinha/diagnóstico , Arthrodermataceae/isolamento & purificação , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Pescoço/microbiologia , Pescoço/patologia , Pele/microbiologia , Tórax/microbiologia , Tórax/patologiaRESUMO
BACKGROUND: Interferon-gamma acts to multiply the potency with which innate interferons (alpha/beta) suppress herpes simplex virus type 1 (HSV-1) replication. Recent evidence suggests that this interaction is functionally relevant in host defense against HSV-1. However, it is not clear which WBCs of the innate immune system, if any, limit HSV-1 spread in an IFN-gamma dependent manner. The current study was initiated to determine if natural killer (NK) cells provide innate resistance to HSV-1 infection, and if so to determine if this resistance is IFN-gamma-dependent. RESULTS: Lymphocyte-deficient scid or rag2(-/-) mice were used to test four predictions of the central hypothesis, and thus determine if innate resistance to HSV-1 is dependent on 1. NK cell cytotoxicity, 2. NK cells, 3. WBCs, or 4. the IFN-activated transcription factor, Stat 1. Loss of NK cell cytotoxic function or depletion of NK cells had no effect on the progression of HSV-1 infection in scid mice. In contrast, viral spread and pathogenesis developed much more rapidly in scid mice depleted of WBCs. Likewise, loss of Stat 1 function profoundly impaired the innate resistance of rag2(-/-) mice to HSV-1. CONCLUSION: Lymphocyte-deficient mice possess a very tangible innate resistance to HSV-1 infection, but this resistance is not dependent upon NK cells.
Assuntos
Herpes Simples/imunologia , Herpesvirus Humano 1/imunologia , Imunidade Inata , Linfócitos/imunologia , Animais , Proteínas de Ligação a DNA/deficiência , Feminino , Interferon gama/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Knockout , Camundongos SCIDRESUMO
Thalidomide has gained an infamous history due to severe birth defects observed in patients who had taken the drug to control nausea during pregnancy. The medication was withdrawn from the market because of its teratogenicity, but was approved by the FDA in 1998 for the treatment of erythema nodosum leprosum. However, thalidomide has been employed with success by dermatologists for a host of off-label uses including the treatment of lichen planus. Currently, no clinical trials or studies exist to evaluate the efficacy of using thalidomide to treat lichen planus, but case reports have been published in the medical literature supporting its therapeutic benefits. TNF-alpha is among the many cytokines that have been implicated in the pathogenicity of lichen planus. It is thought that thalidomide acts.
Assuntos
Imunossupressores/uso terapêutico , Líquen Plano/tratamento farmacológico , Talidomida/uso terapêutico , Adulto , Complicações do Diabetes/tratamento farmacológico , Feminino , Hepatite C/complicações , Humanos , Líquen Plano/patologia , Pele/patologiaRESUMO
Rickettsial and ehrlichial infections are both carried by arthropod vectors. Both Rickettsia and Ehrlichia are small intracellular gram-negative coccobacilli. Clinical manifestations of Rickettsia range from spotted fevers to various forms of typhus. Human ehrlichiosis can present as monocytic ehrlichiosis or granulocytic anaplasmosis. Prevention is by avoidance of the responsible vectors. Therapy is usually with doxycycline, but chloramphenicol can also be used.