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1.
Sci Rep ; 11(1): 12314, 2021 06 10.
Artigo em Inglês | MEDLINE | ID: mdl-34112902

RESUMO

We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. One of these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, and endothelial activation, presented elevated insulinemia, glycemia, triglyceridemia, and γ-glutamyl transferase, a marker of liver injury, in comparison with other profiles. Our data are compatible with a model in which a particular immune activation profile might favor the development of insulin resistance and metabolic syndrome. In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis.


Assuntos
Inflamação/imunologia , Resistência à Insulina/imunologia , Síndrome Metabólica/imunologia , Linfócitos T/imunologia , gama-Glutamiltransferase/genética , Idoso , Linfócitos B/imunologia , Biomarcadores/sangue , Glicemia , Linfócitos T CD4-Positivos/imunologia , Senescência Celular/genética , Fígado Gorduroso/genética , Fígado Gorduroso/imunologia , Feminino , Humanos , Inflamação/genética , Inflamação/patologia , Resistência à Insulina/genética , Masculino , Síndrome Metabólica/genética , Síndrome Metabólica/patologia , Pessoa de Meia-Idade , Monócitos/imunologia , Linfócitos T/patologia
2.
Sci Rep ; 10(1): 20824, 2020 11 30.
Artigo em Inglês | MEDLINE | ID: mdl-33257766

RESUMO

Latent infectious agents, microbial translocation, some metabolites and immune cell subpopulations, as well as senescence modulate the level and quality of activation of our immune system. Here, we tested whether various in vivo immune activation profiles may be distinguished in a general population. We measured 43 markers of immune activation by 8-color flow cytometry and ELISA in 150 adults, and performed a double hierarchical clustering of biomarkers and volunteers. We identified five different immune activation profiles. Profile 1 had a high proportion of naïve T cells. By contrast, Profiles 2 and 3 had an elevated percentage of terminally differentiated and of senescent CD4+ T cells and CD8+ T cells, respectively. The fourth profile was characterized by NK cell activation, and the last profile, Profile 5, by a high proportion of monocytes. In search for etiologic factors that could determine these profiles, we observed a high frequency of naïve Treg cells in Profile 1, contrasting with a tendency to a low percentage of Treg cells in Profiles 2 and 3. Moreover, Profile 5 tended to have a high level of 16s ribosomal DNA, a direct marker of microbial translocation. These data are compatible with a model in which specific causes, as the frequency of Treg or the level of microbial translocation, shape specific profiles of immune activation. It will be of interest to analyze whether some of these profiles drive preferentially some morbidities known to be fueled by immune activation, as insulin resistance, atherothrombosis or liver steatosis.


Assuntos
Imunidade Celular/fisiologia , Células Matadoras Naturais/imunologia , Monócitos/imunologia , Linfócitos T/imunologia , Idoso , Variação Biológica da População , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Imunológicos , Linfócitos T Reguladores/imunologia
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