Long-term clinical results of 33 thumb replantations.

INTRODUCTION: Thumb replantation following complete amputation is a relatively frequent and well-established surgical procedure. In literature many studies report a discrepancy between the objective measurements and the subjective satisfaction of the patients. Nowadays, evaluation of the patient long-term benefit obtained by replantation is uncertain. The aim of this study was to consider the long-term results of 33 thumb replantation procedures. METHODS: The period considered is from January 1997 to December 2015, 33 subjects fulfilled the study inclusion criteria and were included in the study. We evaluated in each patient: ROM (performing Kapandji test), level and mechanism of amputation, force peak of three grips using Dexter dynamometer (five-handle, key, tri-digital grips), sensibility (using Disk-Criminator and aesthesiometers of Semmes-Weinstein) and subjective perception of disability (using DASH questionnaire). RESULTS: All patients were males, 94% of them returned to their previous occupation. Average follow-up was 9±4 years. The prevalent mechanism of injury was a combined amputation in 58% of cases. Levels involved in more than half of patients were interphalangeal joints and proximal phalanxes. Ratios of strength recovery were: for the five-handle grip equal to 0.90±0.28 kg (p=0.63), 0.78±0.30 kg (p=0.64) for key grip and 0.75±0.32 kg (p=0.78) for tri-digital grip. Results for Kapandji test was 8±2 and for DASH test was 16±21. The protective tactile threshold was recovered in 49% of patients; S2PD test resulted positive in 54% and D2PD test in 39% of cases. CONCLUSIONS: Results confirm and strengthen evidence of positive long-term functional outcomes of thumb replantation interventions.

Cold intolerance and neuropathic pain after peripheral nerve injury in upper extremity.

Cold intolerance and pain can be a substantial problem in patients with peripheral nerve injury. We aimed at investigating the relationships among sensory recovery, cold intolerance, and neuropathic pain in patients affected by upper limb peripheral nerve injury (Sunderland type V) treated with microsurgical repair, followed by early sensory re-education. In a cross-sectional clinical study, 100 patients (male/female 81/19; age 40.5 ± 14.8 years and follow-up 17 ± 5 months, mean ± SD), with microsurgical nerve repair and reconstruction in the upper extremity and subsequent early sensory re-education, were evaluated, using Cold Intolerance Symptoms Severity questionnaire-Italian version (CISS-it, cut-off pathology >30/100 points), CISS questionnaire-12 item version (CISS-12, 0-46 points-grouping: healthy that means no cold intolerance [0-14], mild [15-24], moderate [25-34], severe [35-42], very severe [43-46] cold intolerance), probability of neuropathic pain (DouleurNeuropathique-4; [DN4] 4/10), deep and superficial sensibility, tactile threshold (monofilaments), and two-point discrimination (cutoff S2; Medical Research Council scale for sensory function; [MRC-scale]). A high CISS score is associated with possible neuropathic pain (DN4 ≥ 4). Both a low CISS-it score (ie, < 30) and DN4 < 4 is associated with good sensory recovery (MRC ≥ 2). In conclusion patients affected by upper limb peripheral nerve injuries with higher CISS scores more often suffer from cold intolerance and neuropathic pain, and the better their sensory recovery is, the less likely they are to suffer from cold intolerance and neuropathic pain.

Psychometric properties of the Italian version of the Cold Intolerance Symptom Severity questionnaire in upper-extremity nerve repair.

BACKGROUND: In upper-limb peripheral nerve injured patients, cold intolerance is the most bothersome, prolonged and disabling symptom, negatively affecting work and leisure activities. The Cold Intolerance Symptom Severity (CISS) questionnaire is widely used to assess this symptom, though its psychometric properties have not been examined in depth and no validated Italian version exists. AIM: The aim of this study was to examine in depth the psychometric properties of the Italian version of CISS (CISS-It) in a sample of patients with upper-limb peripheral nerve injury. DESIGN: Prospective cross-sectional. SETTING: Outpatient. POPULATION: Seventy-two subjects with upper-limb peripheral nerve injury consecutively admitted for outpatient assessment and rehabilitation. METHODS: We assessed dimensionality, reliability, validity, and responsiveness (minimum detectable change, MDC) of the CISS-It by means of Classical Test Theory methods. RESULTS: Factor analysis confirmed the scale's unidimensionality. Internal consistency (alpha=0.93) and test-retest reliability (ICC2,1 =0.96) were high. The convergent validity of the CISS-It was demonstrated by its correlations with the 4-item Douleur Neuropathique (DN4) Scale (rs=0.73), pain score (rs=0.61), and Medical Research Council (MRC) Scale for sensory function (rs=-0.44). The MDC95 was 11.30 points. CONCLUSIONS: CISS-It is a reliable, valid and easy-to-use questionnaire for measuring cold intolerance in subjects with upper-limb peripheral nerve injury. However, there is room for some refinement of the CISS structure and wording, which we suggest to perform within the framework of modern statistical methods (such as Rasch analysis), in order to optimize content coverage and technical quality of the measurement. CLINICAL REHABILITATION IMPACT: This examination in depth of the psychometric properties of the CISS further increases confidence in the scale's use for clinical assessment and monitoring of abnormal cold sensitivity in the rehabilitation of patients with upper extremity peripheral nerve injury.

Development of a simplified Cold Intolerance Symptom Severity questionnaire in patients with peripheral nerve injury.

The aim of this study was to analyse the Cold Intolerance Symptom Severity (CISS) questionnaire in its Italian validated version, using Rasch analysis, to gain insights for a possible refinement of the questionnaire. The CISS was administered to a convenience sample of 96 consecutively recruited outpatients with upper limb peripheral nerve injury. Data were analysed using Rasch analysis. According to rating scale diagnostics, response options of items 3 and 5 did not comply with the pre-set criteria for an optimal category functioning. After collapsing the malfunctioning categories, all items fitted the measured construct. Principal component analysis of standardized residuals showed local dependence between two items (one of them was considered redundant and deleted); after this deletion, unidimensionality of the 12-item questionnaire (CISS-12) was achieved. The reliability indices of CISS-12 were high (>0.85). Some clearer item wording was introduced in response to comments from an expert panel and patient feedback. Overall, Rasch analysis provided the rationale for improving the measurement qualities of the questionnaire, refining its rating scales, identifying those items most useful for measuring the intended construct and confirming the high reliability of its person-ability and item-difficulty estimates. In conclusion, the new simplified CISS-12 presents robust psychometric properties for measuring cold intolerance in patients with upper limb peripheral nerve injury and represents a solid basis for clinical studies aimed at a precise (interval level) measurement of cold-induced symptoms in these patients.

Evaluation of the Effectiveness of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty: A Meta-Analysis.

OBJECTIVE: The aim of the study was to evaluate the efficacy of the use of the neuromuscular electrical stimulation after total knee arthroplasty. DESIGN: The study used a systematic review of randomized controlled trials (MEDLINE, PubMed, Cochrane Library, and PEDro) using Patient Population or Problem, Intervention, Comparison, Outcomes, Setting approach to formulate the research question, controlled terms, and Boolean operators. Inclusion and exclusion criteria were defined in advance. "Neuromuscular electrical stimulation" and "total knee arthroplasty" were used as keywords. The overall risk of bias was determined according to the following: random sequence generation, concealment, blinding mass of participants and staff, commissioning blind assessment results, incomplete data, and loans received. RESULTS: Of the 36 identified studies, six were included in the review (496 participants). In these studies, one group of patients followed a rehabilitation protocol (control group) and the other followed a rehabilitation program plus a session of neuromuscular electrical stimulation (neuromuscular electrical stimulation group). Patients of neuromuscular electrical stimulation groups got the best scores (timed up and go test, stair climbing test, and walk test). Neuromuscular electrical stimulation benefits were strong in the first postoperative weeks/months and gradually diminished. CONCLUSIONS: Neuromuscular electrical stimulation allows a slightly better functional recovery after total knee arthroplasty, especially in the first period, with more evident benefits in patients with a severe lack of muscular activation. Nevertheless, there is no difference at medium-long term.

Ultrasound-guided pulse-dose radiofrequency: treatment of neuropathic pain after brachial plexus lesion and arm revascularization.

Neuropathic pain following brachial plexus injury is a severe sequela that is difficult to treat. Pulsed radiofrequency (PRF) has been proved to reduce neuropathic pain after nerve injury, even though the underlying mechanism remains unclear. This case report describes the use of ultrasound-guided PRF to reduce neuropathic pain in a double-level upper extremity nerve injury. A 25-year-old man who sustained a complete left brachial plexus injury with cervical root avulsion came to our attention. Since 2007 the patient has suffered from neuropathic pain (NP) involving the ulnar side of the forearm, the proximal third of the forearm, and the thumb. No pain relief was obtained by means of surgery, rehabilitation, and medications. Ultrasound-guided PRF was performed on the ulnar nerve at the elbow level. The median nerve received a PRF treatment at wrist level. After the treatment, the patient reported a consistent reduction of pain in his hand. We measured a 70% reduction of pain on the VAS scale. PRF treatment allowed our patient to return to work after a period of absence enforced by severe pain. This case showed that PRF is a useful tool when pharmacological therapy is inadequate for pain control in posttraumatic neuropathic pain.

Functional and subjective results of 20 thumb replantations.

The aim of this retrospective study was to analyse the results of 20 thumb replantations with special and exhaustive attention on functional outcomes. Twenty patients with traumatic thumb amputation were enrolled in the study. Range of motion, grip strength, sensory recovery, and subjective perception of overall hand function recovery were measured. The average age at the time of surgery was 35 years (range, 13-73 years). The mean follow-up was 3.25 years (range, 1.9-10.25 years). The long-term results of thumb replantation confirmed satisfactory outcomes in terms of general upper limb function, handgrip and pinch strength, and social and work reintegration. Sensory recovery remained unsatisfactory despite the fact that we did not need to perform any kind of revision surgery as a consequence of inadequate thumb sensibility. For the first time in the existing literature, no functional parameter that contributes to the assessment of the function of replanted thumbs has been excluded. We resume in the same study the analysis of all functional parameters that are useful to define results of thumb replantation.