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1.
Sci Transl Med ; 10(434)2018 03 28.
Artigo em Inglês | MEDLINE | ID: mdl-29593103

RESUMO

The resurgence of pertussis over the past decades has resulted in incidence levels not witnessed in the United States since the 1950s. The underlying causes have been the subject of much speculation, with particular attention paid to the shortcomings of the latest generation of vaccines. We formulated transmission models comprising competing hypotheses regarding vaccine failure and challenged them to explain 16 years of highly resolved incidence data from Massachusetts, United States. Our results suggest that the resurgence of pertussis is a predictable consequence of incomplete historical coverage with an imperfect vaccine that confers slowly waning immunity. We found evidence that the vaccine itself is effective at reducing overall transmission, yet that routine vaccination alone would be insufficient for elimination of the disease. Our results indicated that the core transmission group is schoolchildren. Therefore, efforts aimed at curtailing transmission in the population at large, and especially in vulnerable infants, are more likely to succeed if targeted at schoolchildren, rather than adults.


Assuntos
Vacina contra Coqueluche/uso terapêutico , Humanos , Vacina contra Coqueluche/imunologia , Estados Unidos , Vacinação/estatística & dados numéricos , Cobertura Vacinal/estatística & dados numéricos
2.
Proc Biol Sci ; 283(1822)2016 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-26763701

RESUMO

Pertussis, a highly contagious respiratory infection, remains a public health priority despite the availability of vaccines for 70 years. Still a leading cause of mortality in developing countries, pertussis has re-emerged in several developed countries with high vaccination coverage. Resurgence of pertussis in these countries has routinely been attributed to increased awareness of the disease, imperfect vaccinal protection or high infection rates in adults. In this review, we first present 1980-2012 incidence data from 63 countries and show that pertussis resurgence is not universal. We further argue that the large geographical variation in trends probably precludes a simple explanation, such as the transition from whole-cell to acellular pertussis vaccines. Reviewing available evidence, we then propose that prevailing views on pertussis epidemiology are inconsistent with both historical and contemporary data. Indeed, we summarize epidemiological evidence showing that natural infection and vaccination both appear to provide long-term protection against transmission and disease, so that previously infected or vaccinated adults contribute little to overall transmission at a population level. Finally, we identify several promising avenues that may lead to a consistent explanation of global pertussis epidemiology and to more effective control strategies.


Assuntos
Coqueluche/epidemiologia , Adulto , Bordetella pertussis/imunologia , Doenças Transmissíveis Emergentes/epidemiologia , Doenças Transmissíveis Emergentes/imunologia , Doenças Transmissíveis Emergentes/transmissão , Reservatórios de Doenças , Humanos , Incidência , Lactente , Recém-Nascido , Vacinação em Massa , Coqueluche/imunologia , Coqueluche/microbiologia , Coqueluche/transmissão
3.
Food Microbiol ; 51: 101-7, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26187834

RESUMO

One of the main challenges for the fresh-food produce industry is to ensure that the produce is free from harmful pathogens. A potential area of risk is due to cross-contamination in a sanitizing chlorine wash-cycle, where the same water is used to wash contaminated as well as non-contaminated produce. However, this is also an area where effective intervention strategies are possible, provided we have a good understanding of the mechanism of cross-contamination. Based on recent experimental work by Luo, Y. et al. A pilot plant scale evaluation of a new process aid for enhancing chlorine efficacy against pathogen survival and cross-contamination during produce wash, International Journal of Food Microbiology, 158 (2012), 133-139, we have built mathematical models that allow us to quantify the amount of cross-contamination of Escherichia coli O157:H7 from spinach to lettuce, and assessed the efficacy of the associated wash-cycle protocols.


Assuntos
Cloro , Escherichia coli O157/crescimento & desenvolvimento , Contaminação de Alimentos , Lactuca/microbiologia , Modelos Teóricos , Spinacia oleracea/microbiologia , Contagem de Colônia Microbiana , Descontaminação , Desinfetantes/farmacologia , Contaminação de Alimentos/estatística & dados numéricos , Manipulação de Alimentos/métodos , Inocuidade dos Alimentos , Água
4.
Proc Biol Sci ; 282(1806): 20150347, 2015 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-25833863

RESUMO

As an emergent infectious disease outbreak unfolds, public health response is reliant on information on key epidemiological quantities, such as transmission potential and serial interval. Increasingly, transmission models fit to incidence data are used to estimate these parameters and guide policy. Some widely used modelling practices lead to potentially large errors in parameter estimates and, consequently, errors in model-based forecasts. Even more worryingly, in such situations, confidence in parameter estimates and forecasts can itself be far overestimated, leading to the potential for large errors that mask their own presence. Fortunately, straightforward and computationally inexpensive alternatives exist that avoid these problems. Here, we first use a simulation study to demonstrate potential pitfalls of the standard practice of fitting deterministic models to cumulative incidence data. Next, we demonstrate an alternative based on stochastic models fit to raw data from an early phase of 2014 West Africa Ebola virus disease outbreak. We show not only that bias is thereby reduced, but that uncertainty in estimates and forecasts is better quantified and that, critically, lack of model fit is more readily diagnosed. We conclude with a short list of principles to guide the modelling response to future infectious disease outbreaks.


Assuntos
Doenças Transmissíveis Emergentes/epidemiologia , Surtos de Doenças , Ebolavirus/fisiologia , Doença pelo Vírus Ebola/epidemiologia , Modelos Teóricos , África Ocidental/epidemiologia , Viés , Doenças Transmissíveis Emergentes/virologia , Doença pelo Vírus Ebola/virologia , Humanos
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