[Increase in T-cell level in the peripheral blood of women with fractures in anamnesis during postmenopause period].

44 postmenopausal patients (45-76 years of old) have been observed. Interrelationship between composition and functional activity of peripheral blood cells, TNF-alpha level in the serum and bone density in postmenopausal women has been analyzed. It was established that the increase in neutrophil activity in women with osteoporosis, the high level of immune complexes are accompanied by the high level of IgG and autoantibodies to DNA. These results allow suggesting the presence of chronic inflammatory or immune processes taken place in postmenopausal women with osteoporosis. Increase in CD3+ cells percent was established in women with fracture in anamnesis. Obtained results allow suggesting the possibility that T-cells may play a role in the occurrence of fractures.

[Age and the vascular reaction to injury]. / Vik ta reaktsiia sudyn na poshkodzhennia.

Our own results and the literature dates analysis showed that spontaneous endothelial cells injury in aging, and the hypertension, hypercholesterinemia, immune disorders, that was induced in experiment aggravating the process of the development of atherosclerosis.

[Age-related changes in glucocorticoid and mineralocorticoid receptors in lymphocytes of healthy persons and patients with hypertension]. / Vikovi zminy retseptoriv gliuko- i mineralokortykoïdiv v limfotsytakh zdorovykh i khvorykh na gipertonichnu khvorobu liudei.

It has been found that the number of glucocorticoid receptors in lymphocytes of the peripheral blood of healthy elderly subjects increases, while the number of mineralocorticoid receptors decreases. The mechanisms of hormone-receptor interactions in hypertension are activated: the number of glucocorticoid and mineralocorticoid binding sites grows in hypertensive patients. Still a more essential rise in the number of receptors is observed in mid-age hypertensive patients than in elderly ones.