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1.
J Electromyogr Kinesiol ; 57: 102515, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33453439

RESUMO

The current study evaluated the effect of a passive neck orthosis, developed for patients suffering from progressive muscular diseases, on neck muscle activity in 10 adult healthy participants. The participants performed discrete head movements involving pure neck flexion (-10 to 30°), pure neck rotation (up to 30° left and right) and combined neck flexion-rotation (-10 to 30°) in steps of 10° by moving a cursor on a screen to reach predefined targets and staying on target for 10 s. Surface electromyography (EMG) was recorded from upper trapezius and sternocleidomastoid muscles and amplitudes were averaged over the static phases in trials with and without the orthosis. Moreover, the variability in head position and time required to perform the tasks were compared between conditions. Wearing the orthosis caused significant reductions (p = 0.027) in upper trapezius activity (a change of 0.2-1.5% EMGmax) while working against gravity. The activity level of the sternocleidomastoid muscle increased (p ≤ 0.025) by 0.3-1.0% EMGmax during pure and combined rotations without any pain reported. The orthosis showed potential to reduce the activity level of the upper trapezius muscle, the main load bearing muscle of the neck. Further study will be carried out to evaluate the effect in different patient groups.


Assuntos
Braquetes/normas , Braquetes/tendências , Debilidade Muscular/terapia , Músculos do Pescoço/fisiologia , Músculos Superficiais do Dorso/fisiologia , Adulto , Eletromiografia/normas , Eletromiografia/tendências , Movimentos da Cabeça/fisiologia , Humanos , Masculino , Contração Muscular/fisiologia , Debilidade Muscular/fisiopatologia , Pescoço/fisiologia , Aparelhos Ortopédicos/normas , Aparelhos Ortopédicos/tendências , Amplitude de Movimento Articular/fisiologia , Adulto Jovem
2.
J Neuroeng Rehabil ; 15(1): 22, 2018 03 14.
Artigo em Inglês | MEDLINE | ID: mdl-29540235

RESUMO

BACKGROUND: Patients with Duchenne muscular dystrophy gradually lose the ability to use different muscles of their body. Consequently, they lose the ability to stabilize their trunk against gravity. This hinders them to effectively perform different daily activities. In this paper, we describe the design, realization and evaluation of a trunk orthosis for these patients that should allow them to move their trunk and maintain stability. METHOD: This study aimed to primarily assess the effectiveness of the trunk support system in terms of unloading of trunk muscles, so only healthy participants were recruited for this phase of the study. Measurements were done on 10 healthy participants (23.4±2.07 [M±SD] years old, average body weight 68.42±24.22 [M±SD] kg). The experiment comprised maintaining a constant trunk posture in three different device conditions (control without orthosis and two conditions with different configurations of the orthosis), at four different flexion angles (10°, 20°, 30°, 40°) for each device condition and for two load conditions (with and without stretching the arms). Electromyography (EMG) signals from the trunk muscles were measured to estimate activation levels of the trunk muscles (iliocostalis, longissimus, external oblique and rectus abdominis) and a motion capture system was used to record the movement of the participants during the experiment. RESULTS: Wearing the orthosis caused reductions in longissimus and iliocostalis activity. The average muscle activity level was 5%-10% of maximum voluntary contraction in the unsupported conditions for those particular muscles. This level was reduced to 3%-9% of maximal voluntary contraction for the supported conditions. No effect on external oblique and rectus abdominis activity was observed. Moreover, no pain or discomfort was reported by any of the participants during the experiment. The results from the current experiment also suggests the necessity of lumber stabilizing systems while using trunk orthosis. CONCLUSION: The developed orthosis reduces trunk muscle activation level and provides a solid step for further development of support systems for Duchenne muscular dystrophy patients. TRIAL REGISTRATION: The current study was approved by the medical ethics committee Arnhem-Nijmegen (study number: NL53143.091.15 ), The Netherlands.


Assuntos
Braquetes , Desenho de Equipamento , Distrofia Muscular de Duchenne/reabilitação , Adulto , Voluntários Saudáveis , Humanos , Masculino , Músculo Esquelético/fisiologia , Postura/fisiologia , Tronco , Adulto Jovem
3.
Artif Organs ; 40(10): 981-991, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26582749

RESUMO

A mock heart circulation loop (MHCL) is a hydraulic model simulating the human circulatory system. It allows in vitro investigations of the interaction between cardiac assist devices and the human circulatory system. In this study, a preload sensitive MHCL, the MHCLAUTO , was developed to investigate the interaction between the left ventricle and left ventricular assist devices (LVADs). The Frank-Starling mechanism was modeled by regulating the stroke volume (SV) based on the measured mean diastolic left atrial pressure (MLAPdiast ). The baroreflex autoregulation mechanism was implemented to maintain a constant mean aortic pressure (MAP) by varying ventricular contractility (Emax ), heart rate (HR), afterload/systemic vascular resistance (SVR) and unstressed venous volume (UVV). The DP3 blood pump (Medos Medizintechnik GmbH) was used to simulate the LVAD. Characteristic parameters were measured in pathological conditions both with and without LVAD to assess the hemodynamic effect of LVAD on the MHCLAUTO . The results obtained from the MHCLAUTO show a high correlation to literature data. The study demonstrates the possibility of using the MHCLAUTO as a research tool to better understand the physiological interactions between cardiac implants and human circulation.


Assuntos
Pressão Atrial , Barorreflexo , Coração Auxiliar , Volume Sistólico , Simulação por Computador , Hemodinâmica , Humanos , Modelos Cardiovasculares , Desenho de Prótese , Função Ventricular Esquerda
4.
Int J Artif Organs ; 37(11): 824-33, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25450316

RESUMO

The aim of this work is to develop a tool to study the effect of sodium nitroprusside (SNP) on hemodynamics in conjunction with baroreflex and mechanical circulatory assistance. To this aim, a numerical model of the pharmacodynamic effect of SNP was developed and inserted into a cardiovascular circulatory model integrated with baroreflex and LVAD (continuous flow pump with atrio-aortic connection) sub-models.The experiments were carried out in two steps. In the first step the model was verified comparing simulations with experimental data acquired from mongrel dogs on mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), peripheral resistance, and left ventricular properties.In the second step, the combined action of SNP and mechanical circulatory assistance was studied. Data were measured at pump off and at pump on (20000 rpm and 24000 rpm). At pump off, with a 2.5 µg/kg per min SNP infusion in heart failure condition, the MAP was reduced by approximately 8%, CO and HR increased by about 16% and 18%, respectively. In contrast, during assistance (24000 rpm) the changes in MAP, CO and HR were around -9%, +12%, and +20%, respectively. Furthermore, the effects of the drug on hemodynamic parameters at different heart conditions were significantly different. Thus, the model provides insight into the complex interactions between baroreflex, drug infusion, and LVAD and could be a support for clinical decision-making in cardiovascular pathologies.


Assuntos
Insuficiência Cardíaca/terapia , Coração Auxiliar , Hemodinâmica/efeitos dos fármacos , Modelos Cardiovasculares , Nitroprussiato/farmacologia , Vasodilatadores/farmacologia , Função Ventricular Esquerda , Animais , Pressão Arterial/efeitos dos fármacos , Barorreflexo/efeitos dos fármacos , Simulação por Computador , Modelos Animais de Doenças , Cães , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/fisiopatologia , Frequência Cardíaca/efeitos dos fármacos , Infusões Intravenosas , Nitroprussiato/administração & dosagem , Análise Numérica Assistida por Computador , Desenho de Prótese , Fatores de Tempo , Resistência Vascular/efeitos dos fármacos , Vasodilatação/efeitos dos fármacos , Vasodilatadores/administração & dosagem
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