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Systemic inflammatory response index (SIRI) has been proven to be associated with the prognosis of coronary artery disease and many other diseases. However, the relationship between SIRI and acute traumatic spinal cord injury (tSCI) has rarely been evaluated. The study aims to assess the prognostic value of SIRI for clinical outcomes in individuals with acute tSCI. A total of 190 patients admitted within eight hours after tSCI between January 2021 and April 2023 were enrolled in our study. Logistic regression analysis was used to analyze the association between SIRI and American Spinal Injury Association Impairment Scale (AIS) grade at admission and discharge, as well as neurological improvement in tSCI patients, and receiver operating characteristic (ROC) analysis was performed to assess the discriminative ability of SIRI in predicting AIS grade at discharge. After adjusting for confounding factors, SIRI positively correlated with the AIS grade (A to C) at admission and discharge, and negatively correlated with neurological improvement. The area under the curve values in ROC analysis was 0.725 (95% CI 0.647, 0.803). The study suggests that SIRI is significantly associated with an increased risk of poor clinical outcome at discharge in tSCI patients and has a certain discriminative value.
Assuntos
Curva ROC , Traumatismos da Medula Espinal , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Prognóstico , Adulto , Idoso , Síndrome de Resposta Inflamatória Sistêmica/diagnóstico , Estudos RetrospectivosRESUMO
BACKGROUND: Sleep deprivation strongly deteriorates the stability of vigilant maintenance. In previous neuroimaging studies of large-scale networks, neural variations in the resting state after sleep deprivation have been well documented, highlighting that large-scale networks implement efficient cognitive functions and attention regulation in a spatially hierarchical organization. However, alterations of neural networks during cognitive tasks have rarely been investigated. METHODS AND PURPOSES: The present study used a within-participant design of 35 healthy right-handed adults and used task-based functional magnetic resonance imaging to examine the neural mechanism of attentional decline after sleep deprivation from the perspective of rich-club architecture during a psychomotor vigilance task. RESULTS: We found that a significant decline in the hub disruption index was related to impaired vigilance due to sleep loss. The hierarchical rich-club architectures were reconstructed after sleep deprivation, especially in the default mode network and sensorimotor network. Notably, the relatively fast alert response compensation was correlated with the feeder organizational hierarchy that connects core (rich-club) and peripheral nodes. SIGNIFICANCES: Our findings provide novel insights into understanding the relationship of alterations in vigilance and the hierarchical architectures of the human brain after sleep deprivation, emphasizing the significance of optimal collaboration between different functional hierarchies for regular attention maintenance.
Assuntos
Imageamento por Ressonância Magnética , Privação do Sono , Adulto , Humanos , Imageamento por Ressonância Magnética/métodos , Vigília/fisiologia , Encéfalo/fisiologia , Atenção/fisiologiaRESUMO
Vigilance instability in the sleep-deprived state was deemed to result from the imbalance in thalamic-FPN-DMN circuits (FPN: frontoparietal network; DMN: default mode network), but the behavioural correlation of this neural hypothesis is still unclear. To address this issue, we applied dynamic functional connectivity (DFC) analysis on the task-based fMRI data and detected high arousal state (HAS) and low arousal state (LAS). Relative to HAS, LAS demonstrated higher positive connectivity within task-positive networks (TPN), attenuated TPN-DMN anti-correlation, and greater anti-correlation between cerebral and subcortico-cerebellar networks. Critically, DFC differences between HAS and LAS were correlated with the ongoing vigilance performance in the sleep-deprived state. The current findings confirmed a direct link between vigilance instability and DFC in the thalamic-FPN-DMN circuits. In particular, we postulated that the integration within task-related system and segregation between task-related system and the subcortico-cerebellar system might be the critical neural markers underlying vigilance instability in the sleep-deprived state.
Assuntos
Mapeamento Encefálico , Privação do Sono , Encéfalo/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Rede Nervosa/diagnóstico por imagem , Redes Neurais de Computação , Vias Neurais/diagnóstico por imagem , Privação do Sono/diagnóstico por imagemRESUMO
A series of studies have shown that sleep loss impairs one's capability for sustained attention. However, the underlying neurobiological mechanism linking sleep loss with sustained attention has not been elucidated. The present study aimed to investigate the effect of sleep deprivation on the resting-state brain and explored whether the magnitude of vigilance impairment after acute sleep deprivation can be predicted by measures of spontaneous fluctuations and functional connectivity. We implemented resting-state functional magnetic resonance imaging with 42 participants under both normal sleep and 24-hr sleep-deprivation conditions. The amplitude of low-frequency fluctuations (ALFF) and functional connectivity was used to investigate the neurobiological change caused by sleep deprivation, and the psychomotor vigilance task (PVT) was used to measure sustained attention in each state. Correlation analysis was used to investigate the relationship between the change in ALFF/functional connectivity and vigilance performance. Sleep deprivation induced significant reductions in ALFF in default mode network nodes and frontal-parietal network nodes, while inducing significant increments of ALFF in the bilateral thalamus, motor cortex, and visual cortex. The increased ALFF in the visual cortex was correlated with increased PVT lapses. Critically, decreased frontal-thalamus connectivity was correlated with increased PVT lapses, while increased frontal-visual connectivity was correlated with increased PVT lapses. The findings indicated that acute sleep deprivation induced a robust alteration in the resting brain, and sustained attentional impairment after sleep deprivation could be predicted by altered frontal connectivity with crucial neural nodes of stimulus input, such as the thalamus and visual cortex.
Assuntos
Imageamento por Ressonância Magnética , Privação do Sono , Atenção , Encéfalo , Humanos , Privação do Sono/diagnóstico por imagem , VigíliaRESUMO
Previous neuroimaging studies have revealed neural representation of traits in the medial prefrontal cortex (mPFC), but related studies mainly investigated the neural representation of warmth or competence trait respectively. To identify the potential differences of trait codes of warmth and competence in the mPFC, we applied functional magnetic resonance imaging (fMRI) repetition suppression which is a rapid reduction of neuronal responses upon repeated presentation of the same implied trait. Participants read two successive trait-implying behavioral descriptions. In each trial, the critical target sentence implied either a warmth-related or competence-related trait was preceded by a prime sentence that implied trait from the other dimension of the 'Big Two' with a same or opposite valence, or no trait. The results revealed robust repetition suppression from prime to target in the mPFC only when the prime was a warmth-related trait, regardless of valence. Critically, the suppression effect was much stronger after being primed with a similar and opposite warmth trait compared with a trait-irrelevant prime. This suppression pattern was found nowhere else in the brain. The result seems to indicate that humans do not completely interpret and represent warmth and competence traits as independent dimensions and the warmth trait is more influential than Competence trait. The finding extends the understanding of the 'Big Two' theory of impression formation from the aspect of neural activity.
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Mapeamento Encefálico , Imageamento por Ressonância Magnética , Encéfalo/diagnóstico por imagem , Humanos , Neuroimagem , Córtex Pré-Frontal/diagnóstico por imagemRESUMO
BACKGROUND: Previous studies have demonstrated that individuals showed higher risk preference in the afternoon than in the morning. However, few studies aimed to explore the alteration of feedback learning effect during risky decision making, which is one of the important psychological processes of real risk behaviors. Moreover, cognitive function altered at the off-peak time due to impaired inhibitory control. The present study is to investigate the time-of-day effect on risky decision making and inhibitory control and whether the alteration of inhibitory control causes the differences in risky decision making across one day. PARTICIPANTS AND METHODS: We adopted a within-participants design without extremely chronotype individuals to measure the time-of-day (9 am vs 3 pm) effect on risky decision making by using the Balloon Analogue Risk Task. At the same time, we measured the inhibitory control by using the Go/no-go task. RESULTS: Our results confirmed that individuals showed higher risk preference in the afternoon than in the morning. In addition, we found that individuals were insensitive to loss and the previous negative feedback in the afternoon. Critically, the results did not reveal any significant correlation between risky decision making and inhibitory control under the regulation of the time-of-day effects, although individuals performed worse on inhibitory control in the afternoon. CONCLUSION: The current findings revealed that the time-of-day effect regulated risky decision making and inhibitory control. Individuals act with higher risk preference, less sensitivity to loss as negative feedback, and lower inhibitory control in the afternoon than in the morning. This may reflect the effects of time-of-day on risk propensity and inhibitory control is relatively independent.
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OBJECTIVE: The aim of our study was to investigate the influences of acute sleep deprivation on cooperation with two classical social dilemmas, the Prisoner's dilemma (PD) and the chicken dilemma (CD). METHODS: All participants (N=24) were required to come for the experiments twice; one time for normal sleep condition, the other time for sleep deprivation condition, with a counter-balanced sequence. In the following afternoon, participants completed the psychomotor vigilance task (PVT) and two social dilemmas tasks, as well as the Karolinska Sleepiness Scale (KSS), the Risk Orientation Questionnaire (ROQ) and the Positive and Negative Affect Schedule (PANAS). RESULTS: Our results demonstrated that sleep deprivation significantly impaired cooperative behaviors in the CD but not in the PD. In addition, this detrimental effect was not related with the alteration in the risk-seeking, objective alertness, subjective sleepiness, and mood. CONCLUSION: The current findings revealed that sleep deprivation impairs cooperative behaviors under social dilemmas selectively. However, the underlying mechanism remains to further explore with neuroimaging studies and better ecological approach.
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Heterogeneity of tumor cells and their microenvironment can affect outcome in cancer. Blockade of immune checkpoints (ICPs) expressed only on a subset of immune cells leads to durable responses in advanced melanoma. Tissue-resident memory T (TRM) cells have recently emerged as a distinct subset of memory T cells in nonlymphoid tissues. Here, we show that functional properties and expression of ICPs within tumor-infiltrating lymphocytes (TILs) differ from those of blood T cells. TILs secrete less IL-2, IFN-γ, and TNF-α compared with circulating counterparts, and expression of VEGF correlated with reduced TIL infiltration. Within tumors, ICPs are particularly enriched within T cells with phenotype and genomic features of TRM cells and the CD16+ subset of myeloid cells. Concurrent T cell receptor (TCR) and tumor exome sequencing of individual metastases in the same patient revealed that interlesional diversity of TCRs exceeded differences in mutation/neoantigen load in tumor cells. These findings suggest that the TRM subset of TILs may be the major target of ICP blockade and illustrate interlesional diversity of tissue-resident TCRs within individual metastases, which did not equilibrate between metastases and may differentially affect the outcome of immune therapy at each site.