[Blood endorphin levels in myocardial infarction]. / Endorfiny krovi pri infarkte miokarda.

Blood gamma-endorphin concentrations were repeatedly measured, using an original radioimmunoassay, in patients with myocardial infarction. In the early days of acute myocardial infarction, high levels of this opioid peptide were observed, then plasma gamma-endorphin concentration gradually decreased by the time of discharge. In patients with grave complications, gamma-endorphin level was significantly lower, as compared to patients with uncomplicated infarction.

[Use of myocardial scintigraphy with Tl-201 and veloergometry in patients with typical stenocardia and atypical pain syndrome]. / Primenenie stsintigrafii miokarda s 201T1 i veloergometrii u bol'nykh s tipichnoi stenocardiei i atipichnym bolevym sindromom.

The results of myocardial scintigraphy with 201Tl used in combination with bicycle ergometry in 19 patients with typical angina and in 41 patients with an atypical pain syndrome are reported. Possible use of a single 201Tl dose at the peak of exercise is considered. The diagnostic value of myocardial scintigraphy with 201Tl was not basically different from that of conventional bicycle ergometry in patients with typical angina, whereas in cases of an atypical pain syndrome myocardial scintigraphy had an essential advantage over bicycle ergometry, which in this case was associated with a noticeably increased number of uncertain or negative results. Total assessment of the exercise test, using both methods, was found to have a higher diagnostic value in both groups.

[Use of nitroglycerin in the treatment of patients with myocardial infarct]. / Isopol'zovanie nitroglitserina pri lechenii bol'nykh infarktom miokarda.

The effect of the intravenous administration of nitroglycerin on the general course of myocardial infarction as well as on such syndromes as acute left ventricular insufficiency, progressive congestive cardiac failure and the recurring painful syndrome was studied. The assessment of the effect of the drug was carried out in relation to its capacity to limit the extension of myocardial infarction and regulate the blood supply to the organs. The data on the frequency and nature of side-effects following nitroglycerin administration are presented. The conclusion is drawn as to the advisability of the drug employment in patients in the acute period of myocardial infarction when it is indicated as well as on the necessity of predicting adverse hemodynamic response to nitroglycerin with the help of suggested diagnostic tests.

[Unresolved problems of the pathogenesis of heart failure in myocardial infarct]. / Nereshennye voprosy patogeneza serdechnoi nedostatochnosti pri infarkte miokarda.

On the basis of the review of their own and literature data, the authors describe a current concept of the development of heart failure in the acute period of myocardial infarction. They also discuss the relationship between the degree of this syndrome and such factors as the extent of necrosis, defects of the regulation of the systemic functions in the first days of the disease, as well as contractility disorders preceding myocardial infarction. The authors suggest original interpretation of the functional impairments in relation to different reactions of acute tension. The pathogenesis of lung oedema and cardiac shock is evaluated from this point of view. The authors stress the necessity and real possibility of prevention of cardiac insufficiency in a considerable proportion of myocardial infarction patients.

[Use of beta-adrenoblockaders in the therapy of the syndromes accompanying acute myocardial infarct]. / Ispol'zovanie beta-adrenoblokatorov v terapii nekotorykh sindromov, soprovozhdaiushchikh ostryi infarkt miokarda.

The use of beta-adrenoblockers in patients with acute myocardial infarction, accompanied by hypertension and hyperdynamia, leads to normalization of the arterial pressure, of parametres of haemo- and cardiodynamics, to a decrease of the degree of ischaemia of the damaged myocardium and to an increase of the heart work efficacy.

[Early diagnostic possibilities in heart failure in myocardial infarct]. / Vozmozhnosti rannei diagnostiki serdechnoi nedostatochnosti pri infarkte miokarda.

In 57 patients on different days of myocardial infarction a comparison of haemodynamic and myocardial contractility parameters was made with their predicted values which were calculated with due consideration of oxygen utilization, arterial pressure and the heart rate. It is established that the majority of patients with myocardial infarction have insufficiency of cardiac output and of contractile activity of the heart beginning with the 1-2d day of illness. At the same time, absolute values of the parameters, stress-caused, can exceed the analogous parameters in patients with ischaemic heart disease outside the period of exacerbation, at rest. It is concluded that the comparison of figures of haemodynamics and contractility with the predicted values constitute an important part in the early diagnosis of cardiac insufficiency.

[Central hemodynamic indices studied by use of a tetrapolar variant of integral rheography of the human body]. / Issledovanie pokazatelei tsentral'noi gemodinamiki s pomoshch'iu tetrapoliarnogo varianta integral'noi reografii tela cheloveka.

Integral rheography is conducted by M. I. Tishchenko's method by means of bipolar rheographs which do not ensure accurate reading of the values which form the formula for determining the stroke volume. A modification of the method is suggested with the use of a tetrapolar diagram of impedance measurement and a technically perfect PPG-202 device with a widened range of measurement of the resistance of the object being studied, which ensures accurate impedance reading and stable calibration. To study the possibilities of the method, comparative investigations by means of the echocardiography and thermodilution methods and by means of the bipolar variant of integral rheography were conducted. The results of the investigations bear evidence that the method described is sufficiently accurate for studying central hemodynamics in the clinic and in the prehospital stage of management of the patients.

[Differential use of glucagon in acute period of myocardial infarct]. / Differentsirovannoe primenenie gliukagona v ostrom periode infarkta miokarda.

The work demonstrates the efficacy of glucagon in acute myocardial infarction and its complications, particularly in bradycardia, hypotension, disorders of cardiac rhythm and conduction, cardiogenic shock, cardiac insufficiency in complete atrioventricular heart block and recurrent forms of ventricular fibrillation. A differential approach and dynamic control over the effect of the drug on the values of hemodynamics, respiration, and metabolism are necessary under the conditions of units of intensive therapy and cardioresuscitation.

[Experience in using integral rheography for evaluating the hemodynamic indices in emergency states in cardiology]. / Opyt ispol'zovaniia integral'noi reografii dlia otsenki gemodinamicheskikh pokazatelei pri neotlozhnykh sostoianiiakh v kardiologii.

The work deals with the comparative assessment of integral rheography, a modern method for studying hemodynamic indices. As compared to the method of dye dilution and radiocardiography, integral rheography has proved to be sufficiently precise and at the same time has definite advantages as a method of express diagnosis in patients with acute cardiovascular diseases. As compared with the other method of indirect determination of the cardiac output, tetrapolar rheography, integral rheography is more suitable for being used in emergencies, particularly in cases with disorders of the rhythm of the cardiac activity.