RESUMO
Psychopharmacological studies were conducted on an extract of Andrographis paniculata herbs. The extract exhibited a significant alteration in behaviour pattern and a reduction in spontaneous motility. The extract also produced a prolongation of the pentobarbitone-induced sleeping time and lowered the body temperature in different experimental animal models.
Assuntos
Comportamento Animal/efeitos dos fármacos , Magnoliopsida , Dor/prevenção & controle , Plantas Medicinais , Psicotrópicos/farmacologia , Convulsões/prevenção & controle , Ácido Acético , Animais , Camundongos , Dor/induzido quimicamente , Medição da Dor/efeitos dos fármacos , Pentilenotetrazol , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Psicotrópicos/uso terapêutico , Ratos , Convulsões/induzido quimicamente , EstricninaRESUMO
The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of Liv-52 a known hepatoprotective formulation.
