RESUMO
RATIONALE: The linear regression of mass spectra is a computational problem defined as fitting a linear combination of reference spectra to an experimental one. It is typically used to estimate the relative quantities of selected ions. In this work, we study this problem in an abstract setting to develop new approaches applicable to a diverse range of experiments. METHODS: To overcome the sensitivity of the ordinary least-squares regression to measurement inaccuracies, we base our methods on a non-conventional spectral dissimilarity measure, known as the Wasserstein or the Earth Mover's distance. This distance is based on the notion of the cost of transporting signal between mass spectra, which renders it naturally robust to measurement inaccuracies in the mass domain. RESULTS: Using a data set of 200 mass spectra, we show that our approach is capable of estimating ion proportions accurately without extensive preprocessing of spectra required by other methods. The conclusions are further substantiated using data sets simulated in a way that mimics most of the measurement inaccuracies occurring in real experiments. CONCLUSIONS: We have developed a linear regression algorithm based on the notion of the cost of transporting signal between spectra. Our implementation is available in a Python 3 package called masserstein, which is freely available at https://github.com/mciach/masserstein.
RESUMO
Based on the current literature authors revised anatomical and clinical datas considering the mandible.
Assuntos
Mandíbula/anatomia & histologia , Mandíbula/inervação , Humanos , Doenças Mandibulares/diagnóstico , Nervo Mandibular , Maxila/anatomia & histologia , Maxila/inervaçãoRESUMO
Foramen of mandible is the most important point considering the Halsted anesthesia. Position of this foramen seems to be stable, however there are lots of controversies regarded to its position. Based on the current literature authors revised datas from literature considering the location of the mandibular foramen.