RESUMO
ABSTRACT: The aim of this study was to retrospectively compare values of thyroid-stimulating hormone (TSH) in adolescent patients diagnosed with schizophrenia, bipolar disorder, unipolar depression (UNI-DEP), conduct disorders (CD), and hyperkinetic disorders.The research involved 1122 patients (718 women, 64%); aged 12 to 18 hospitalized in the Department of Adolescent Psychiatry, Medical University of Lodz. We analyzed TSH levels in the whole study population and compared it between the above-mentioned subgroups of diagnoses.Mean serum TSH concentration in the studied population (nâ=â1122) was 2.06âµIU/mL. The values of percentiles were as follows: 2.5th - 0.53âµIU/mL, 10th - 0.89âµIU/mL, 25th - 1.31âµIU/mL, 50th - 1.9âµIU/mL, 75th - 2.6âµIU/mL, 90th - 3.43âµIU/mL, 97.5th - 4.72âµIU/mL. TSH values were negatively correlated with patients' age (Pâ=â.00001). Patients with bipolar depression had higher TSH levels than patients with CD (Pâ=â.002). Also, when male and female groups were examined separately we found that female patients with UNI-DEP and bipolar disorder had higher TSH levels than female patients with CD (Pâ=â.001; Pâ=â.001).Our results confirm that there may be a higher prevalence of thyroid dysfunctions in bipolar and UNI-DEP subgroups among adolescents and that it is worthy to consider some kind of interventions regarding thyroid function in depressed individuals.