RESUMO
AIM: To investigate effects of trimetazidine and perindopril on myocardial function and metabolism in patients with cardiac failure after myocardial infarction. MATERIAL AND METHODS: A comparative study was mode of the effects of 6-month therapy with perindopril, trimetazidine alone and in combination on clinical symptoms, left ventricular function and perfusion, glucose utilization, excretion and utilization of fatty acids in the zones of postinfarction scar, periinfarction ischemia and in without infarction changes. RESULTS: Combined treatment with the ACE inhibitor and trimetazidine produced positive clinical and functional-metabolic shifts in postmyocardial infarction patients with cardiac failure. CONCLUSION: The addition to the program of mild cardiac failure treatment early after myocardial infarction of an ACE inhibitor and a cytoprotective drug (trimetazidine) promotes more complete clinical compensation of the patients.
Assuntos
Baixo Débito Cardíaco/tratamento farmacológico , Fármacos Cardiovasculares/uso terapêutico , Infarto/complicações , Contração Miocárdica/efeitos dos fármacos , Miocárdio/metabolismo , Adulto , Idoso , Pressão Sanguínea/efeitos dos fármacos , Baixo Débito Cardíaco/etiologia , Baixo Débito Cardíaco/metabolismo , Baixo Débito Cardíaco/fisiopatologia , Fármacos Cardiovasculares/administração & dosagem , Quimioterapia Combinada , Eletrocardiografia , Metabolismo Energético/efeitos dos fármacos , Ácidos Graxos não Esterificados/metabolismo , Glucose/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Perindopril/administração & dosagem , Perindopril/uso terapêutico , Trimetazidina/administração & dosagem , Trimetazidina/uso terapêuticoRESUMO
Central hemodynamic changes were investigated in 88 patients with essential hypertension after 5-year supervision. With adequate treatment the circulation type common to a given form of hypertension was basically preserved so that no hemodynamic changes were noted. The natural course of the disease was associated with considerably increased total peripheral resistance, while eu- and hypokinetic, instead of hyperkinetic, circulation gradually began to prevail in patients with labile hypertension. Plasma renin activity and renal cortical blood flow decreased. These changes are conducive to the stabilization and progress of arterial hypertension.
