RESUMO
Energy and structural parameters of monochromanes and trimethylphenols derivatives have been chracterized through the employment of semiempirical methods of quantum chemistry. The correlation has been proved between antiradical, hepatoprotective properties of these compounds and energy and structural of their molecules that confirms the presence of relation between structure activity and electron-donor properties of the investigated monochromanes and trimethylphenols.
Assuntos
Antioxidantes/farmacologia , Cromanos/farmacologia , Fígado/efeitos dos fármacos , Modelos Químicos , Fenóis/farmacologia , Teoria Quântica , Animais , Antioxidantes/química , Fenômenos Químicos , Cromanos/química , Transporte de Elétrons , Retículo Endoplasmático/efeitos dos fármacos , Retículo Endoplasmático/metabolismo , Membranas Intracelulares/efeitos dos fármacos , Membranas Intracelulares/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Fígado/metabolismo , Fenóis/química , Ratos , Relação Estrutura-AtividadeRESUMO
Using some biochemical and physico-chemical methods of investigation, antioxidant activity and membrane protective effect of derivatives of monochromanes and trimethylphenols has been studied most active inhibitors of lipoperoxidation and the compounds capacity to structural modification of properties of the surface and hydrophobic zones of phospholipids bilayer in membranes of endoplasmic reticulum of the liver cells of rats have been determined.
