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1.
Vopr Med Khim ; 41(4): 28-30, 1995.
Artigo em Russo | MEDLINE | ID: mdl-8571582

RESUMO

The experiments on 6-Gy irradiated rats have revealed that the new biologically active substance. Glucosuccine has a radioprotective effect which depends upon the route of administration. The agent was demonstrated to produce a profound radioprotective rather than therapeutical effects. Its administration for 30 days proved to be less effective than its triple use prior to and following irradiation.


Assuntos
Glucosamina/análogos & derivados , Lesões Experimentais por Radiação/prevenção & controle , Protetores contra Radiação/farmacologia , Animais , Glucosamina/farmacologia , Masculino , Lesões Experimentais por Radiação/sangue , Ratos , Ratos Wistar
2.
Farmakol Toksikol ; 42(3): 285-7, 1979.
Artigo em Russo | MEDLINE | ID: mdl-446713

RESUMO

Tests on rabbits revealed the aromatic sulfohydrazides and their derivatives to display hypoglycemic action. A number of compounds superior to butamide by their sugar-lowering action and of low toxicity were discovered. The relationship between the chemical structure of the study substances and their hypoglycemic action is discussed.


Assuntos
Hidrazinas/farmacologia , Hipoglicemiantes , Sulfonas/farmacologia , Animais , Glicemia/análise , Avaliação Pré-Clínica de Medicamentos , Masculino , Coelhos , Fatores de Tempo , Tolbutamida/farmacologia
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