[Association of cardiovascular system and endothelial dysfunction indicators in patients with hemorrhagic shock].

UNLABELLED: Endothelial dysfunction is a universal mechanism of pathogenesis of many critical conditions. Goal of the study was to assess a relation of cardiovascular system and endothelial dysfunction indicators in patients with hemorrhagic shock. MATERIALS AND METHODS: 17 patients with hemorrhagic shock 3 were involved in the study. All patients received infusion therapy, artificial lung ventilation after tracheal intubation and symptomatic treatment in prehospital period. Common volume of blood loose was 2900 +/- 200 mL. The patients received infusion, transfusion, inotrope, antibacterial, respiratory and symptomatic therapy in ICU after surgical treatment. Cardio-vascular system parameters were assessed by Tischenko method of integral reography. Number of red cells, hemoglobin, lactate, endotelin-1 and Wb-factor of venous blood were studied before surgery, in 12 and in 24 hours after. Morphological study of the omentumbiopsy was carried out. RESULTS: Performed correlation analysis showed statistically significant relations of cardiovascular system and endothelial dysfunction indicators in patients with hemorrhagic shock. Endothelial dysfunction occurs in patients with hemorrhagic shock 3. The endothelial dysfunction correlates with parameters of cardio-vascular system and tissue perfusion.

[Immunological parameters in diabetic patients with septic shock].

The paper describes early postoperative changes in the parameters of phagocytosis, cellular and humoral immunities in 33 patients with type 2 diabetes mellitus in the phase of decompensation along with diffuse purulent peritonitis and septic shock. Just on admission to an intensive care unit, the patients were found to have secondary immune deficiency and the performed therapy failed to correct the parameters of phagocytosis and cellular and humoral immunities. Impaired immunological responsiveness progressed to the maximum manifestations by the end of 7 days.

[Impact of postoperative early enteral feeding on hemodynamics, oxygen and nutritive status in patients with colonic malignancies concurrent with type 2 diabetes mellitus].

A hundred and one patients (51 males and 50 females) aged 66.2 +/- 5.0 years who had Stages II-III colonic malignancies concurrent with type 2 diabetes mellitus were examined. Two algorithms of postoperative management using the traditional diet and early enteral feeding were comparatively analyzed. The use of an early enteral feeding protocol improves central hemodynamics, oxygen and nutritive status, prevents moderate protein-energy deficiency in the early postoperative period, and reduces the number of complications and deaths in patients with colonic malignancies concurrent with type 2 diabetes mellitus.

[Effects of efferent therapy on the blood oxygen transporting function in diffuse suppurative peritonitis in patients with diabetes mellitus]. / Vliianie éfferentnoi terapii na kislorodtransportnuiu funktsiiu krovi pri razlitom gnoinom peritonite u bol'nykh sakharnym diabetom.

Twenty patients with non-insulin-dependent diabetes mellitus were treated in intensive care wards for diffuse purulent peritonitis developing during diabetes decompensation. Group 1 (10 pts) were treated by basic therapy after surgery, in group 2 (10 pts) basic therapy was supplemented by hemoquantum, efferent, and oxidative therapy with consideration for endotoxicosis phases. Basic therapy during the early postoperative period did not remove disorders in the blood oxygen-transporting function, while sessions of hemoquantum, efferent, and oxidative therapy supplementing basic therapy with consideration for the phases of endotoxicosis improved this function due to decrease of intoxication, diabetes compensation, and increase of cardiac output.

[Complex prevention of thrombotic complications in patients with colorectal cancer during different stages of surgical treatment]. / Kompleksnaia profilaktika tromboticheskikh oslozhenenii u bol'nykh kolorektal'nym rakom na étapakh khirurgicheskogo lecheniia.

Time course of parameters characterizing vascular platelet and coagulation hemostasis was studied in 83 patients with colorectal cancer before, during, and for 7 days after surgery. Before the intervention the disorders in regulation of the blood aggregate state present as chronic disseminated intravascular coagulation (DIC) syndrome. The intervention induces the development of subacute DIC syndrome. During the postoperative period disorders in hemostasis system manifest by chronic hypercompensated DIC syndrome. Thrombotic complications during the postoperative period were prevented by fraxiparin 2 h before the intervention and then during 5 days of the postoperative period in a daily dose of 7500 units anti-Ca (about 100 units/kg) and verapamil starting from day 1 after surgery in a dose of 0.2-0.3 mg/kg for 3 days.