A molecular epidemiological study of rabies in Puerto Rico.

The mongoose is the principal reservoir for rabies on the island of Puerto Rico. This report describes a molecular epidemiological study of representative rabies viruses recovered from the island in 1997. Two closely related but distinct variants circulating in regionally localised parts of the island were identified. The lack of a monophyletic relationship of these viruses suggests that two independent incursions of rabies onto the island have occurred. Both of these Puerto Rican variants were closely related to a variant, known as the north central skunk strain, currently circulating in North American skunk populations and all are members of the cosmopolitan rabies lineage spread during the colonial period. However, the Puerto Rican viruses are clearly distinct from those presently circulating in mongooses in Cuba and which are epidemiologically closely linked to the Mexican dog rabies virus. This study clearly establishes the distinct origins of the rabies viruses now circulating on these two Caribbean islands.

Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp.).

An apparently normal, non-tuberculin-reacting, splenectomized owl monkey presented tuberculosis-like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid-fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.

Hernia del nucleo pulposo lumbar quirúrgico en el Hospital Militar Central de Lima en el periodo 1988 a 1994

Se estudiaron 75 historias clínicas de pacientes con diagnóstico de pacientes con Hernia de Núcleo Pulposo Lumbar, la mayoría de pacientes se encontraron entre los 20 y 30 años de edad siendo más frecuente en los varones en una relación de 5 a 1. En un 57 por ciento hay antecedente traumático y hay relación con a actividad ocupacional, el cuadro clínico que predominó fue la lumbociática, la HNP es más frecuente en La izquierda. El tipo de operación frecuente fue la Hemilaminectomia, disectomia, seguida de laminectomia. Las complicaciones se limitaron a la alteración pasajera de la micción (retención urinaria), la estancia operatoria fue menor en dos semanas en la mayoría de casos. Finalmente en estudio anátomo-patológico, mostró en la mayoría de los casos, fibrocartilago con zonas de degeneración y necrosis. Se hizó una revisión de las últimas publicaciones en nuestro medio sobre esta enfermedad, comentando y comparando nuestros resultados

Breve historia del SIDA en los primates no humanos y su contribución al estudio del síndrome de inmunodeficiencia adquirida / Brief history of AIDS in non-human primates and its contribution to the study of acquired imunodeficiency syndrome

Infection of the rhesus monkey (Macaca mulatta) with retroviruses originating from African non human primates (SIV) induces in this species an acquired immunodeficiency syndrome (SAIDS) closely resembling AIDS in humans. Analogies between the SIV-rhesus system and AIDS in humans are described in this work, analyzing the close relationship existing between the HIV and SIV viruses, and the similarities between SIV disease in the rhesus and HIV disease in humans. A review of current advances in AIDS vaccine research, using the SIV-rhesus model, is also included

Renal clearance and excretion of endogenous substances in the owl monkey.

The clearance and excretion of creatinine, calcium, phosphorus, sodium, and potassium by the kidney was evaluated in 62 owl monkeys using timed urine collections and quantitative urinalyses. The endogenous clearance of creatinine was determined for each monkey. Urinary electrolyte excretion and fractional electrolyte excretions (FE) were measured. Linear regression analysis was used to calculate the correlation between urinary excretion and FE for each electrolyte. The coefficient of determination for each analyte was significant (P ⩽ .0001). Determination of FE was found to be an appropriate indicator of the renal handling of electrolytes and, when viewed in conjunction with urinalysis and other serum parameters, an aid in evaluating renal function in the owl monkey. © 1992 Wiley-Liss, Inc.