1.
Thorax
; 56(9): 737-9, 2001 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11514697
RESUMO
Although restrictive lung disease is the predominant abnormality of pulmonary function in patients with thalassaemia major (TM), its aetiology and its association with pulmonary hypertension (PH) detected in some patients with TM remains unknown. We report a patient with TM, iron overload, frequent pulmonary infections, and progressive severe precapillary PH over the previous 5 years. A severe restrictive pattern and interstitial lung fibrosis were revealed by pulmonary function tests and high resolution computed tomography, respectively. This presentation suggests that interstitial fibrosis may complicate lung involvement in TM and can significantly contribute to the development of PH.
Assuntos
Hipertensão Pulmonar/etiologia , Ferro/metabolismo , Fibrose Pulmonar/etiologia , Talassemia beta/complicações , Adulto , Cateterismo Cardíaco , Eletrocardiografia , Humanos , Hipertensão Pulmonar/diagnóstico por imagem , Masculino , Testes de Função Respiratória , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento , Ultrassonografia , Disfunção Ventricular Direita/etiologia , Talassemia beta/metabolismo
2.
Intensive Care Med
; 26(8): 1157-8, 2000 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11030176