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1.
Vestn Oftalmol ; 140(1): 45-56, 2024.
Artigo em Russo | MEDLINE | ID: mdl-38450466

RESUMO

In recent years, there has been a growing interest in the contribution of neuroretinal degeneration to the pathogenesis of diabetic retinopathy (DR). PURPOSE: This study assesses the effect of the drug Retinalamin on the functional state of the retina in patients with DR using the Diopsys NOVA Vision Testing System that utilizes electrophysiological (EP) technology. MATERIAL AND METHODS: The study included patients with type 1 and 2 diabetes mellitus (DM) with DR of any stage without macular edema. Patients underwent standard ophthalmological examination and objective functional examination of the retina using the Diopsys NOVA Vision Testing System. The control group consisted of patients with type 1 and 2 DM with DR who did not receive Retinalamin. RESULTS: Significant changes in pattern electroretinography and flash electroretinography parameters were recorded in patients who received a course of Retinalamin. Two clinical examples are presented, which can be designated as the first experience of objective functional monitoring of treatment of patients with DR with Retinalamin. CONCLUSION: Retinoprotective therapy is necessary already at the early stages of DR. Electroretinography is an objective tool for functional analysis of the earliest changes in retinal cells in DR. It is necessary to use the identified "therapeutic" window for the appointment of retinoprotective agents.


Assuntos
Diabetes Mellitus Tipo 1 , Diabetes Mellitus Tipo 2 , Retinopatia Diabética , Humanos , Retinopatia Diabética/diagnóstico , Retinopatia Diabética/tratamento farmacológico , Retinopatia Diabética/etiologia , Retina/diagnóstico por imagem , Eletrorretinografia
2.
Vestn Oftalmol ; 140(1): 79-85, 2024.
Artigo em Russo | MEDLINE | ID: mdl-38450470

RESUMO

This article contains up-to-date information on the features of ophthalmological and dermatological manifestations of human immunodeficiency virus (HIV) infection based on the analysis of studies published in 2018-2022. The article also presents a description of a clinical case of HIV infection in a 54-year-old female patient with synchronous manifestation of eye symptoms in the form of retinal vasculitis of the optic nerve head and Kaposi's sarcoma localized on the skin of the face.


Assuntos
Infecções por HIV , Oftalmologia , Disco Óptico , Feminino , Humanos , Pessoa de Meia-Idade , Infecções por HIV/complicações , Infecções por HIV/diagnóstico , Pele
3.
Vestn Oftalmol ; 127(2): 8-15, 2011.
Artigo em Russo | MEDLINE | ID: mdl-21721264

RESUMO

Comparative analysis of retinal structure was performed in patients with POAG and control healthy group using spectral OCT and histology. An apparent similarity of tomographic and histological patterns of retinal changes was found in patients with POAG. These results make OCT potentially appropriate method for vital examination of retinal structure in glaucomatous eyes including early stages of the disease. Degeneration of all retinal layers is revealed. Blood flow deficiency due to sclerosis and hyalinosis of uveal vessels is considered to be an immediate cause of outer and intermediate retinal layers degeneration.


Assuntos
Glaucoma de Ângulo Aberto/patologia , Fluxo Sanguíneo Regional/fisiologia , Retina/citologia , Degeneração Retiniana/patologia , Vasos Retinianos/fisiopatologia , Tomografia de Coerência Óptica/métodos , Seguimentos , Glaucoma de Ângulo Aberto/complicações , Glaucoma de Ângulo Aberto/fisiopatologia , Humanos , Pessoa de Meia-Idade , Degeneração Retiniana/etiologia , Degeneração Retiniana/fisiopatologia , Vasos Retinianos/patologia , Índice de Gravidade de Doença
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