[The treatment potentials of plasmapheresis in glomerulonephritis]. / O lechebnykh vozmozhnostiakh plazmafereza pri glomerulonefrite.

Plasmapheresis (PA) was used in the treatment of 26 patients with primary glomerulonephritis (GN) and in 12 patients suffering from secondary GN. In spite of large volumes of plasma exfusions and their high rate, the authors did not notice that PA produced a beneficial effect on the main symptoms of GN. The clinical effect due to PA was attained in one patient with pseudo-tuberculous interstitial nephritis. Some parameters of homeostasis considerably improved and/or returned to normal for a brief period. The initial refractory nature of GN as regards the immunotropic agents and/or its hormonal dependence did not reduce after PA. It has been shown that replenishment of the removed protein within the range of 10 to 50% does not interfere with the reserve potentialities of restorative protein synthesis in GN patients.

[Intensive plasmapheresis (programs, laboratory monitoring, complications)]. / Intensivnyi plazmaferez (programmy, laboratornyi kontrol', oslozhneniia).

Experience gained with the use of plasmapheresis in 336 children with different diseases is described. In patients with bacterial and inflammatory processes, the effect was attained after the first plasmapheresis session. Acuity of the immunomediated processes decreased after exfusion of 2-3.5 volumes of the circulating plasma. The replacement of the exfused plasma by protein blood preparations was made only in patients with hepatodystrophy, bacterial and inflammatory diseases, and immune complex diseases combined with the signs of consumption coagulopathy. After a course of plasmapheresis there was a significant lowering of total protein, albumin and immunoglobulin G. The reduction of the content of hemoglobin and red blood cells was related to hemodilution Iron homeostasis remained unchanged. The use of plasmapheresis in atopic dermatitis without preventive administration of an antibiotic is associated with the risk of the development of post-catheterization thrombophlebitis.

[Plasmapheresis in clinical practice]. / Plazmaferez v klinicheskoi praktike.

The authors presented their experience of the use of intermittent plasmapheresis in 220 children with bacterial-inflammatory and immune-mediated diseases characterized by extreme severity and refractoriness to common therapeutic methods. Its use against a background of adequate etiological and pathogenetic therapy was shown to improve therapeutic results. In virus hepatitis with liver insufficiency, bullous erythema and hemorrhagic vasculitis plasmapheresis can be used as an independent method. Differentiated programs of the use of plasmapheresis were proposed, its safety was shown.