[Substantiation of the use of pepsidil in secretory insufficiency of the digestive glands caused by antitubercular drugs]. / Obosnovanie ispol'zovaniia pepsidila pri sekretornoi nedostatochnosti pishchevaritel'nykh zhelez, vyzvannoi protivotuberkuleznymi preparatami.

The experiments on rats were undertaken to study the action of pepsidil to make up for the biosynthesis deficiency of digestive enzymes in the stomach and pancreas caused by antituberculous drugs (methazide + PAS, isoniazid + PAS, isoniazid + rifampicin + ethambutol). It was proved that pepsidil reduced an inhibiting action of antituberculous drugs on the activity of gastroenteric tract proteinases. The given condition should be taken into account when antituberculous treatment is conducted.

[Enzyme-forming function of digestive glands after administration of polypeptide C, copepsidyl and panintestine]. / Fermentoobrazuiushchaia funktsiia pishchevaritel'nykh zhelez pod vliianiem polipeptida C, kopepsidila i panintestina.

Polypeptide C (molecular weight 2640 Dalton) extracted from artificial gastric juice), copepsidyl (containing high dosage of pepsin) and panintestine (polyenzyme drug) are studied for their effect on the activity of digestive enzymes of glandular gastric element pancreas and small intestine of rats. It is established that all mentioned drugs stimulate enzymogenesis in the analyzed organs. The activity of pepsin increases in homogenates of gastric mucosa, the activity of trypsin, total proteinases, carboxypeptidase and amylase grows in pancreas homogenates, and that of leucineaminopeptidase--in small intestine.