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Acta Pol Pharm ; 73(6): 1467-1474, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29634100

RESUMO

Simple, precise and accurate densitometric methods were developed for the determination of two antihistamine drugs. rupatadine and fexofenadine. Silica gel 60 F254 HPTLC plates were used as stationary phase, while mixtures of acetonitrile - water - 25% ammonia (90 : 10 : 1, v/v/v) and acetonitrile - methanol -acetate buffer at pH 5.5 (3 : 2 : 5, v/v/v) were used as mobile phases for rupatadine and fexofenadine, respectively. The detection of rupatadine and fexofenadine was conducted out at 256 and 210 nm, respectively. The limit of detection and the limit of quantification for rupatadine were found to be 0.3 and 0.1 µg/spot, respectively, and for fexofenadine, 5 and 2 µg/spot, respectively.


Assuntos
Ciproeptadina/análogos & derivados , Densitometria/métodos , Antagonistas dos Receptores Histamínicos H1/análise , Terfenadina/análogos & derivados , Ciproeptadina/análise , Limite de Detecção , Reprodutibilidade dos Testes , Terfenadina/análise
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