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An Acad Bras Cienc ; 86(3): 1147-50, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25029361

RESUMO

In this study we evaluated the action of crude aqueous extracts obtained from rhytidome of Hymenaea stigonocarpa (jatobá-do-cerrado) on Allium cepa meristematic root cells in three concentrations: 0.082, 0.164, 0.328g/mL, at exposure times of 24 and 48 h. The slides were prepared by the crushing technique, and cells analyzed throughout the cell cycle, totaling 5000 for each control group and concentration. It was found that all three concentrations, including the lowest which is considered ideal for use, in all exposure times, had significant antiproliferative action on the cell cycle of this test system. For cells under division, we observed a high number of cells in prophase. Therefore, under the conditions studied H. stigonocarpa indicated to be cytotoxic.


Assuntos
Ciclo Celular/efeitos dos fármacos , Hymenaea/química , Cebolas/citologia , Cebolas/efeitos dos fármacos , Extratos Vegetais/farmacologia , Raízes de Plantas/efeitos dos fármacos , Relação Dose-Resposta a Droga , Hymenaea/classificação , Hymenaea/citologia , Raízes de Plantas/citologia , Fatores de Tempo
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