[The initial symptom attributable to cancer in digestive tube tumors. A study of agreement between the patient and the physician]. / El síntoma inicial atribuible al cáncer en los tumores del tubo digestivo. Un análisis de la concordancia entre el paciente y el médico.

BACKGROUND: Clinical practice shows that certain patients may underestimate and others overestimate some initial symptoms of their disease. In studies on the interval between first symptoms and treatment onset, estimating the date in which symptoms first appeared is crucial. The study analyzed patient-physician agreement in assessing first symptom attributable to cancer. METHODS: During two years, two physicians personally interviewed, through a structured questionnaire, all symptomatic patients with a neoplasm of the digestive tract admitted to Hospital del Mar (Barcelona, Spain). Patients had a mid-low sociocultural profile and most had been admitted through the Emergency Department. RESULTS: Absolute agreement (symptom and date) occurred in 85% of the 183 subjects. In most discordant cases, patients had overlooked some component of the "toxic syndrome", and the date of symptom onset was, based on physician's assessment, chronologically prior to the date elicited from the patient. Disagreement was directly related to the patient's health status (p < 0.05) and to the number of reported symptoms until hospital admittance (p = 0.002), but not to tumour stage. Agreement increased with the importance attributed by the patient to the first symptom (p < 0.05). CONCLUSIONS: In spite of difficulties inherent to measuring symptomatic onset of diseases, structured patient interviews appear to be a reasonably valid method and deserve further development in this and other areas of research.

[A descriptive study of 105 patients with cerebral metastasis]. / Estudio descriptivo de 105 pacientes con metástasis cerebrales.

BACKGROUND: To investigate the hospital frequency and natural history of patients with cerebral metastases (CM). METHODS: A retrospective study of patients seen because of CM from 1984 to 1989. They were identified from the discharge reports and the cancer registry (CR). Data of interest were taken from the clinical record and the CR. RESULTS: 105 patients were identified. Mean age was 60 years. There were 77 males. In 44 patients cancer past history was present, in 33 lung cancer was simultaneously diagnosed and in 28 there was no past cancer history and the primary neoplasm was not identified. CM were multiple in 49 patients. In 18 patients CM was single, with no extracerebral neoplasia. Craniotomy was carried out in 22 patients and 11 received postoperative radiotherapy. The probability of one-year survival in the operated and nonoperated group was 27% and 1.5%, respectively (27 +/- 20% and 1.5% +/- 1.5%; 95% confidence intervals). CONCLUSIONS: The frequency of the diagnosis of CM is not negligible and its occurrence virtually always represents a fatal prognosis. About one half are caused by a lung cancer that may have clinically presented with CM. Poor general condition, multiple CM or extracerebral neoplastic disease prevent radical therapeutic intervention in nearly 80% of these patients. Survival with palliative therapy is shorter than that with surgical treatment.