1.
Bioorg Med Chem Lett
; 10(1): 45-8, 2000 Jan 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10636240
RESUMO
Tripeptide-derived molecules incorporating C-terminal ketone electrophiles were evaluated as reversible inhibitors of the cysteine-containing human rhinovirus 3C protease (3CP). An optimized example of such compounds displayed potent 3CP inhibition activity (K = 0.0045 microM) and in vitro antiviral properties (EC50=0.34 microM) when tested against HRV serotype-14.