[Evaluation of the quality of radiopharmaceutics]. / Otsenka kachestva radiofarmatsevticheskikh preparatov.

The authors considered the interrelationship of clinical requirements and analytical indicators of quality for a group of pharmaceuticals: radionuclide purity (by the criteria of dose load and the quality of visualization); radiochemical purity (interrelationship with a necessary level of accumulation in investigated organs); chemical admixtures (by the criteria of safety and influence on the diagnostic quality; clinical criteria of quality were under discussion); a coefficient of differential accumulation in the system: organ under study-adjacent tissues; specificity; indices of pharmacokinetics, etc. Correct and all-round evaluation of RP quality on the basis of the above criteria determines, to a great extent, a choice of a labeled compound to be used in a specific radionuclide diagnostic method.

Methods of producing radionuclides for spectrometric gamma-ray sources and their standardization--2. Europium-152.

The radionuclide 152Eu was produced by irradiating 151Eu2O3 or 151EuCl3 enriched to 98.9% with thermal neutrons. 152Eu was separated from rare-earth impurities by extraction chromatography on a column using 0.6 M nitric acid eluent. The specific activity of the 152Eu was 1-10 Ci/g of Eu. The impurity of the 154Eu did not exceed 0.1%. The activity standardization of 152Eu was carried out by extrapolation of 4 pi (beta, e, x)-gamma coincidences. The relative gamma-ray intensities for 28 gamma-ray energies emitted in 152Eu decay have been measured.