Toward Sleep Study Automation: Detection Evaluation of Respiratory-Related Events.

The diagnosis of sleep disordered breathing depends on the detection of respiratory-related events: apneas, hypopneas, snores, or respiratory event-related arousals from sleep studies. While a number of automatic detection methods have been proposed, their reproducibility has been an issue, in part due to the absence of a generally accepted protocol for evaluating their results. With sleep measurements this is usually treated as a classification problem and the accompanying issue of localization is not treated as similarly critical. To address these problems we present a detection evaluation protocol that is able to qualitatively assess the match between two annotations of respiratory-related events. This protocol relies on measuring the relative temporal overlap between two annotations in order to find an alignment that maximizes their F1-score at the sequence level. This protocol can be used in applications which require a precise estimate of the number of events, total event duration, and a joint estimate of event number and duration. We assess its application using a data set that contains over 10,000 manually annotated snore events from 9 subjects, and show that when using the American Academy of Sleep Medicine Manual standard, two sleep technologists can achieve an F1-score of 0.88 when identifying the presence of snore events. In addition, we drafted rules for marking snore boundaries and showed that one sleep technologist can achieve F1-score of 0.94 at the same tasks. Finally, we compared this protocol against the protocol that is used to evaluate sleep spindle detection and highlighted the differences.

Improving Machine Learning Technology in the Field of Sleep.

The authors discuss the challenges of machine- and deep learning-based automatic analysis of obstructive sleep apnea with respect to known issues with the signal interpretation, patient physiology, and the apnea-hypopnea index. Their goal is to provide guidance for sleep and machine learning professionals working in this area of sleep medicine. They suggest that machine learning approaches may well be better targeted at examining and attempting to improve the diagnostic criteria, in order to build a more nuanced understanding of the detailed circumstances surrounding OSA, rather than merely attempting to reproduce human scoring.

Strangely mined bitcoins: Empirical analysis of anomalies in the bitcoin blockchain transaction network.

The blockchain technology introduced by bitcoin, with its decentralised peer-to-peer network and cryptographic protocols, provides a public and accessible database of bitcoin transactions that have attracted interest from both economics and network science as an example of a complex evolving monetary network. Despite the known cryptographic guarantees present in the blockchain, there exists significant evidence of inconsistencies and suspicious behavior in the chain. In this paper, we examine the prevalence and evolution of two types of anomalies occurring in coinbase transactions in blockchain mining, which we reported on in earlier research. We further develop our techniques for investigating the impact of these anomalies on the blockchain transaction network, by building networks induced by anomalous coinbase transactions at regular intervals and calculating a range of network measures, including degree correlation and assortativity, as well as inequality in terms of wealth and anomaly ratio using the Gini coefficient. We obtain time series of network measures calculated over the full transaction network and three sub-networks. Inspecting trends in these time series allows us to identify a period in time with particularly strange transaction behavior. We then perform a frequency analysis of this time period to reveal several blocks of highly anomalous transactions. Our technique represents a novel way of using network science to detect and investigate cryptographic anomalies.