RESUMO
Pulmonary function was assessed in non-sensitized male guinea pigs (206-445 g) before and after intratracheal (ITr) treatment with saline or selenium (Se, 0.06 mg/100 g body weight) as selenium dioxide (SeO2) or seleno-L-methionine (SeM). Pulmonary functional parameters such as the respiratory rate (f), tidal volume (TV), dynamic lung compliance (Cdynl) and lung resistance (Rl) were determined using the respiratory flow (F) signal and the transpulmonary signal obtained via the intrapleural pressure (P) from the animal. Although, pulmonary dysfunction was observable with exposure to two different Se compounds, the SeO2-induced changes in f and Rl were significant (P < 0.05). Treatment with SeM did not result in alteration of any of the parameters significantly. Results indicated that acute ITr SeO2 exposure affects respiration precipitated by a significantly decreased f and an increased Rl unlike after SeM. The Cdynl did not change significantly after treatment with either of the two Se compounds. Comparing the immediate effects of the two different Se compounds on respiration, acute ITr SeO2 exposure was found to be more detrimental to pulmonary function than SeM.
Assuntos
Mecânica Respiratória/efeitos dos fármacos , Compostos de Selênio/toxicidade , Selenometionina/toxicidade , Animais , Cobaias , Intubação Intratraqueal , Pulmão/efeitos dos fármacos , Pulmão/fisiologia , Masculino , Ventilação Pulmonar/efeitos dos fármacos , Testes de Função Respiratória , Óxidos de SelênioRESUMO
The purpose of this study was to determine the effect of cadmium (Cd) or Cd and selenium (Se) administered simultaneously on plasma glucose level. Male Sprague-Dawley derived rats (180-300 g), maintained under controlled environmental conditions, were segregated into fed and 24-h fasted groups prior to experimentation. Each group consisted of 3 subgroups which received one of the following treatments intraperitoneally: sodium acetate (NaAc) (1.23 mg/kg), Cd (0.84 mg/kg) or a combination of Se and Cd (1.6 and 0.84 mg/kg respectively). Plasma glucose was measured before and 30, 60, 120, 180, 240, 300 or 360 min after treatment. Results indicate that both Cd and concurrent administration of Se and Cd induce hyperglycemia in fed and fasted rats.
