RESUMO
The application of the cryopreserved preparation of UCB NCs was accompanied by an enhanced activity of all the neurohumoral regulation elements of heart rate, although the absolute indices in 18- and 24-month-old animals did not reach similar ones in younger age groups. Also we noted an increase of thyroid hormone content in blood serum of aged rats, the level of which decreased with age. In addition, there was shown that the introduction of UCB NCs during animal life cycle (every 6 months) allowed keeping a functional state of the autonomic nervous system at a «young¼ physiological level.
Assuntos
Envelhecimento/fisiologia , Sistema Nervoso Autônomo/fisiologia , Criopreservação , Sangue Fetal , Neurotransmissores/metabolismo , Animais , Sangue Fetal/fisiologia , Sangue Fetal/transplante , Coração/inervação , Coração/fisiologia , Frequência Cardíaca/fisiologia , RatosRESUMO
Effect of various duration of hypokinesia on structural-metabolic characteristics of the lumbar vertebral segment has been studied in Wistar rats. Hypokinesia results in certain morphological changes of the spongy bone and tissues of the intervertebral disk, demonstrating as delayed processes of ossification, disturbed course of organization into bundles of collagenous fibers of the fibrous ring, widening of the nucleus pulposus zone. Polarization-optical investigations reveal some disturbances in the macro-molecular organization of collagen, expressed as decreasing degree of its refraction and as redistribution of glycosaminoglycans towards increasing sulfated keratan sulfates.