[The influence of short wavelength ultraviolet radiation on the healing of thermal wounds (an experimental study)]. / Vliyanie korotkovolnovogo ul'trafioletovogo oblucheniya na zazhivlenie ozhogovykh ran (eksperimental'noe issledovanie).

The topicality of the problem stated in the title of the this article is attributable to the lack of up-to-date information on the treatment of thermal skin wounds with the use of short wavelength ultraviolet radiation (UVR). The objective of the present study was to evaluate the effectiveness of the courses of short wavelength ultraviolet radiation under experimental conditions using a model of standardized thermal skin wounds in rabbits starting from the proliferative phase of the healing. MATERIAL AND METHODS: The experiments were carried out on 24 grey rabbits. The thermal wounds were inflicted using a special device at a temperature of 180 degrees Celsius with a 3 sec exposition. The BOP-4 apparatus operated in the 180-280 nm wavelength range was used to treat the wounds. The total length of the treatment course was 10 days with wound irradiation during 8 to 12 minutes every other day (a total of 5 irradiation sessions throughout the study period). The study methods included morphological ones (microscopy of hematoxylin-eosin and Van Gieson-stained samples, planimetry), hematological (complete blood count), biochemical (general clinical), and microbiological (wound infestation). RESULTS: The study has demonstrated the acceleration of the wound healing process as appeared from the contraction and epithelialization of the lesions, the reduction of microbial infestation, the improvement of the general condition of the animals, and positive dynamics of the hematological and biochemical parameters. CONCLUSION: The results of the present study give evidence that shortwave ultraviolet irradiation is a highly efficient method for the treatment of the thermal skin wounds and the data obtained themselves provide an additional confirmation of the evidence-based effectiveness of light therapy.

[Modern technologies for extraction of balneological medicines from mineral waters].

A new technology for isolation of medicinal balneological preparations from mineral waters has been developed. It is based on the extraction of biologically active compounds (BAC) from mineral waters with ethanol following oxidative hydrolysis and water vapour distillation. This technology has no analogs both in this country and abroad. Unlike ordinary balneological medicines, those obtained by the new method do not contain inorganic matrix, show higher activity, and remain stable for a longer period. The primary composition of BACs isolated by the above technology was studied using solid-phase extraction and chromatomass-spectrometry. Analysis of Extramine, a medicinal preparation from Novonukutskaya hydrogen sulfide mineral water (Siberian Matsesta), allowed to identify active components responsible for its therapeutic effects and elucidate mechanisms of their action. The 15-year-long experience with practical application of BACs obtained with the help of the new technology has demonstrated that they possesses antiallergic, antiviral, and analeptic activities. These compounds increase general resistance of the organism to infection, promote removal of toxic substances, accelerate wound and injury healing, and prevent the development of herpes infection.

[Effect of Novonukutskaya mineral water extracts on the clinical course of wound disease and wound healing in experiment].

The objective of the present work was to study the wound-healing potential of the new preparation, Extramin (a 32% ethanol extract of organic substances from Novonukutskaya mineral water) in a series of experiments on a model of chemical burns in rabbits. The wound healing process was monitored based on biochemical, hematiological, and morphological indicators. Analysis of the results allows for the conclusion that Extramin is a powerful stimulator of the wound-healing processes and can be recommended for further clinical studies.