RESUMO
We used specific histochemical fluorescence-microscopic method of visualization of catecholamines to study adrenergic innervation of the thyroid gland tissue, blood vessels of the thyroid gland, cervical lymphatic vessel and lymph nodes in rats during correction of hypothyroidism with a bioactive formulation (Vozrozhdenie Plus balm with Potentilla alba L.). In experimental hypothyroidism, adrenergic innervation of the thyroid gland and the wall of the cervical lymph node, concentrated mainly along the arterial vessels and the cervical lymphatic vessel, retained its structural formations (plexuses and varicosities), but diffusion of catecholamines outside these formations was observed. Correction with the bioactive formulation restored of the contours of the nerve plexuses and varicosities and their brighter fluorescence in the thyroid gland and cervical lymphatic vessel and node. During correction of hypothyroidism with the bioactive formulation, reorganization of regional lymphatic vessels and nodes was more pronounced than reorganization of the thyroid gland.
Assuntos
Hipotireoidismo , Linfonodos/patologia , Vasos Linfáticos/patologia , Glândula Tireoide/irrigação sanguínea , Glândula Tireoide/inervação , Fibras Adrenérgicas/efeitos dos fármacos , Fibras Adrenérgicas/patologia , Fibras Adrenérgicas/ultraestrutura , Animais , Vasos Sanguíneos/diagnóstico por imagem , Vasos Sanguíneos/efeitos dos fármacos , Vasos Sanguíneos/patologia , Hipotireoidismo/diagnóstico por imagem , Hipotireoidismo/tratamento farmacológico , Hipotireoidismo/patologia , Linfonodos/diagnóstico por imagem , Linfonodos/efeitos dos fármacos , Vasos Linfáticos/diagnóstico por imagem , Vasos Linfáticos/efeitos dos fármacos , Masculino , Microscopia de Fluorescência , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Iodeto de Potássio/farmacologia , Iodeto de Potássio/uso terapêutico , Ratos , Glândula Tireoide/diagnóstico por imagem , Glândula Tireoide/efeitos dos fármacos , Hormônios Tireóideos/farmacologia , Hormônios Tireóideos/uso terapêuticoRESUMO
Adrenergic innervation in the tissue of the thyroid gland, blood vessels of the thyroid gland, cervical lymphatic vessel, and lymph nodes in rats with hypothyroidism was studied by using a specific histochemical fluorescent-microscopic method of visualization of catecholamines. The presence of adrenergic innervation in the blood and lymph vessels and nodes was demonstrated. In hypothyroidism, diffusion of norepinephrine from nerve fibers and varicose thickenings was observed in the wall of the upper and lower thyroid arteries and adjacent cervical lymphatic vessels and nodes.
