[Effects of sodium nucleinate on immunological and nonspecific responsiveness in elderly and senile patients]. / Bliianie nukleinata natriia na immunologicheskuiu i nespetsificheskuiu reaktivnost' bol'nykh tuberkulezom pozhilogo i starcheskogo vozrasta.

Sixty-two elderly and senile patients with pulmonary tuberculosis were examined. Of them 32 had multimodality therapy involving sodium nucleinate. The inclusion of sodium nucleinate into a complex of therapeutical measures for the patients promotes improvement of T-cellular immunity. The patients taking sodium nucleinate were also found to have enhanced specific immunity against tuberculosis. In these patients, stimulation of immunity and nonspecific responsiveness is accompanied by the higher clinical benefits of treatment, as shown by shorter periods in abacillation, in the cessation of signs of intoxication, and in the resolution of infiltrative events and in the closure of decay cavities.

[Immunity of middle age and aged patients with tuberculosis and its changes during multimodality treatment by using T-activin]. / Immunologicheskii status bol'nykh tuberculezom pozhilogo i starcheskogo vozrasta i ego izmeneniia v protsesse kompleksnogo lecheniia s ispol'zovaniiem T-aktivina.

Fifty six patients with pulmonary tuberculosis were examined. Of them 30 had T-activin in multimodality treatment. To supplement the agent in elderly and old patients was found to elevate the counts of T lymphocytes and T helper cells, to normalize Tx/Tc ratios, to enhance T lymphocytic activity and IL-2 synthesis. At the same time there was an increase in nonspecific responsiveness: enhancement of NKC activity and IL-1 synthesis by macrophages. With this, stimulation of specific antituberculous immunity took place. Normalization of immunological responsiveness and stimulation of specific antituberculous immunity were associated with enhanced therapeutical efficiency.

[Immune status of middle-aged and aged patients with tuberculosis]. / Immunnyi status bol'nykh tuberkulezom u lits pozhilogo i starcheskogo vozrasta.

After examination of 165 tuberculous patient of presenile and senile age, 150 young patients, 65 healthy presenile and senile donors, 56 young healthy donors it was established that young and aged healthy donors differ by some parameters of T-cell immunity (inhibited blast-transformation response to PHA, reduced number of T-helpers, high suppressive activity of induced Con-A. Young tuberculous patients differ from their healthy counterparts by a variety of immunological parameters (low T-lymphocyte and helper count, poor blast-transformation, increased number of T-suppressors and induced ConA suppression, B-lymphocyte count and serum IgG level). Immunological reactivity is the least in aged tuberculous patients. Compared to aged healthy donors they have reduced number of T-lymphocytes, T-helpers, inhibited PHA response and IL-2 synthesis, greater count of T-suppressors, enhanced induced ConA suppression. B-cell immunity was similar in young and aged patients. Antituberculous immunity reactions were weaker than in young patients.