RESUMO
Open and double blind trials in 80 patients with proved and definite rheumatoid arthritis have shown that piroxicam possesses marked analgesic and antiinflammatory action, is well tolerated producing a therapeutic effect only at high doses exceeding the mean ones recommended in the literature.
Assuntos
Artrite Reumatoide/tratamento farmacológico , Piroxicam/uso terapêutico , Adulto , Cápsulas , Ensaios Clínicos como Assunto , Relação Dose-Resposta a Droga , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Piroxicam/administração & dosagem , ComprimidosRESUMO
Patients with exacerbation of rheumatoid arthritis without antiinflammatory therapy demonstrated no regular circadian variations in clinical-laboratory indices of disease activity. A study of the therapeutic effect of 3 schemes with naproxen has shown that one should consider the time of development of maximum arthralgia in each individual patient and administer the drug 1 hour before it at quite a large single dose. The drug concentration in the blood plasma of the rheumatoid arthritis patients corresponded, on an average, to an administered dose showing no parallelism with a clinical effect of the drug.
