RESUMO
We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of the disease.
Assuntos
Glutationa Transferase/genética , Intoxicação/genética , Polimorfismo Genético , Criança , Intervalos de Confiança , Humanos , Razão de Chances , Intoxicação/enzimologiaRESUMO
The 6beta-hydroxycortisol/cortisol ratio was measured in 52 children aging 1.1-14.0 years. The maximum increment in this ratio occurred in the age interval of 1.1-2.0 years. During this period, the regression coefficients in the linear (r=0.57; p=0.044) and nonlinear logarithmic models (r=0.56; p=0.049) were similar. At the age of 10-14 years, the examined ratio attained 19.17+/-17.79.
Assuntos
Sistema Enzimático do Citocromo P-450/metabolismo , Adolescente , Criança , Pré-Escolar , Humanos , Hidrocortisona/análogos & derivados , Hidrocortisona/urina , LactenteRESUMO
We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).
Assuntos
Asma/genética , Dermatite Atópica/genética , Glutationa Transferase/genética , Polimorfismo Genético , Alelos , Criança , Feminino , Genótipo , Homozigoto , Humanos , Isoleucina/química , Masculino , Razão de Chances , Risco , Federação Russa , Valina/química , Xenobióticos/farmacologiaRESUMO
The frequency of individual genotypes GSTM1, GSTT1, and GSTP1 and haplotypes was determined in patients with atopic dermatitis and healthy children. The actual frequency of some haplotypes was far below the theoretical value. Some haplotypes were associated with predisposition and resistance to atopic dermatitis.
Assuntos
Dermatite Atópica/genética , Predisposição Genética para Doença , Genótipo , Glutationa Transferase , Isoenzimas , Adolescente , Alelos , Estudos de Casos e Controles , Criança , Pré-Escolar , Dermatite Atópica/epidemiologia , Feminino , Frequência do Gene , Glutationa S-Transferase pi , Haplótipos , Humanos , Lactente , Masculino , Razão de Chances , Polimorfismo Genético , Federação Russa/epidemiologiaRESUMO
Therapy of acute decompensated forms of laryngotracheitis in children has not been well developed. The mortality rate as a result of asphyxia reaches 10 to 52%. The present authors were able to reduce significantly the number of hazardous complications and lethal outcomes when treating 32 children with acute decompensated forms of laryngotracheitis (only one patient died). This was achieved by using prolonged (from 6 hrs to 19 days) intubation of the trachea, intensive medicine and physical therapy methods. Special attention was given to intubation tubes and drugs used. The postintubation course was smooth and no complications in the trachea were seen after treatment.
