The prevalence of Carbapenem Resistance Gram negative pathogens in a Tertiary Teaching Hospital in Jordan.

BACKGROUND: With the absence of new antimicrobial drugs being developed to replace those facing resistance, bacterial resistance continues to grow. Despite previous studies conducted in various countries, there is a lack of comprehensive local reporting on the occurrence of carbapenem resistance among gram-negative bacteria. OBJECTIVE: This study aims to identify the prevalence of carbapenem-resistant gram-negative bacterial isolates. METHOD: A retrospective cross-sectional study was conducted at an academic hospital in Jordan over an eight-month period, spanning from November 2021 to June 2022. The study involved screening electronic medical records to identify patients with clinical cultures showing the growth of Gram-negative bacteria. Antimicrobial susceptibility results of the Gram-negative isolates were recorded. RESULTS: A total of 1,043 isolated Gram-negative bacteria were analyzed for carbapenem susceptibility. Among the species tested, the most common carbapenem-resistant bacteria were Acinetobacter baumannii (153/164, 93.3%), followed by Klebsiella pneumonia (184/311, 59.2%), and Pseudomonas aeruginosa (67/160, 41.9%). The least commonly isolated species resistant to carbapenem were Escherichia coli (25/361, 6.9%) and Proteus mirabilis (1/30, 3.3%). None of Serratia marcescens or Proteus vulgaris isolates were resistant to carbapenem (0%). Overall, the prevalence of carbapenem-resistance gram-negative isolates was 41.2% (430 out of 1,043). CONCLUSION: This study provides population-specific data that are crucial for guiding empirical antimicrobial treatment decisions not only within the participating hospital but also in other nearby healthcare facilities. The results underscore the urgent need for coordinated efforts to address antibiotic resistance in Jordan. Comprehensive measures such as strict infection control methods, annual nationwide surveillance programs, and effective antimicrobial stewardship programs at the national level are imperative to reduce the overuse of broad-spectrum antibiotics.

Jordanians' knowledge, attitude and practice regarding adverse drug reactions reporting.

Objectives: The purpose of the current study was to evaluate the general public knowledge, attitudes, and practice regarding Adverse Drug Reactions (ADRs) reporting and pharmacovigilance in Jordan. Methods: A cross-sectional study was conducted between July 16, 2022, and July 30, 2022, in Jordan. During the study period, an electronic survey consisting of 4 sections was administered to a convenience sample of Jordanians (aged 18 or above) using 2 social media platforms (Facebook and WhatsApp). Logistic regression analysis was used to screen the predictors of ADRs reporting by the participants. Results: A total of 441 participants completed the survey. The majority of the participants (67.6%) were females, 53.1% between 26 and 45 years old. Almost all participants (96.3%) were always aware of the indication of the medications they take, the time and frequency (87.8%), and the duration of medications (84.4%). Nearly one-third of the participants (37.4%) asked about their medications' ADRs. However, the drug information leaflet was the most frequently used source of ADR information (33.3%). The majority of responders believed that both healthcare providers and consumers should report ADRs (93.4% and 80.3%, respectively). Only one-quarter of respondents (27.2%) believed that consumers could directly report ADRs through the Jordan pharmacovigilance program. The majority of patients who had experienced ADRs (70.3%) were aware that ADRs should be reported, and among them, 91.9% had reported the ADRs to healthcare providers. Furthermore, few participants (8.1%) reported it to the Jordan National Pharmacovigilance Centre (JNCP). Linear regression revealed that none of the demographic characteristics (age, gender, education, job, and social status) were affecting public reporting practice of the ADRs (P > 0.05 for all). Conclusion: Respondents showed fair knowledge about adverse drug reactions and their reporting. However, there is a need to initiate educational activities and intervention programs to raise awareness about the JNPC, which will have a positive impact on public health and ensure safe medication use in Jordan.

The impact of educational interventional session on healthcare providers knowledge about pharmacovigilance at a tertiary Jordanian teaching hospital.

OBJECTIVE: A limited number of educational interventions among health care providers and students have been made in Jordan concerning the pharmacovigilance. Therefore, the main aim of this study was to evaluate how an educational workshop affected the understanding of and attitudes toward pharmacovigilance among healthcare students and professionals in a Jordanian institution. METHODS: A questionnaire was used before and after an educational event to evaluate the pre- and post-knowledge and perception of pharmacovigilance and reporting of adverse drug reactions (ADRs) among a variety of students and healthcare professionals at Jordan University Hospital. RESULTS: The educational workshop was attended by 85 of the 120 invited healthcare professionals and students (a response rate of 70.8%). The majority of respondents were capable of defining ADRs (n = 78, 91.8%) and pharmacovigilance accurately (n = 74, 87.1%) in terms of their prior understanding of the topic. Around 54.1% of the participants (n = 46) knew the definition of type A ADRs while 48.2% of them (n = 41) knew the definition of type B ADRs. Additionally, around 72% of the participants' believed that only serious and unexpected ADRs should be reported (n = 61, 71.8%), also, 43.5% of them (n = 37) believed that ADRs should not be reported until the specific medication that caused it is known. The majority of them (n = 73, 85.9%) agreed that reporting of ADRs was their responsibility. The interventional educational session has significantly and positively impacted participants' perceptions (p value ≤ 0.05). The most reason for not reporting ADRs as stated by the study participants was the lack of information provided by patients (n = 52, 61.2%) and the lack of enough time to report (n = 10, 11.8%). CONCLUSION: Participants' perspectives have been greatly and favorably impacted by the interventional educational session. Thus, ongoing efforts and suitable training programs are required to assess the effect of bettering knowledge and perception on the practice of ADRs reporting.

Is COVID-19 multisystem inflammatory syndrome a new variant of Kawasaki Disease?

Objectives: In this systematic review, we aimed to evaluate the clinical features, therapeutic options, and outcomes of children with multisystem inflammatory syndrome in children (MIS-C) and to investigate whether MIS-C is a new variant of Kawasaki disease. Materials and methods: Adhering to PRISMA principles, we searched for eligible studies between December 2019 and June 2020 through the following databases: PubMed, ISI Web of Science, SCOPUS, and Science Direct. Studies including original data of patients aged <21 years with MIS-C and descriptions of clinical signs, laboratory or radiological investigations were selected. Results: A total of 84 studies were identified, for which 48 were eligible for full screening and only 13 studies (n=657) met our inclusion criteria. More than 70% of patients with MIS-C tested positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The most common symptoms were gastrointestinal (80 to 100%) and most patients presented with fever for >4 days. Mucocutaneous manifestations are similar to Kawasaki disease presented in up to 64% in some studies. Almost all patients had significant elevations in inflammatory markers, and up to 50 to 100% had elevated troponin suggesting myocardial damage. Intravenous immunoglobulin (IVIG) was administered to 60% of patients in 12 studies and 80 to 100% in five studies. Steroids were administered to 10 to 95% of patients. The overall mortality rate was 0.9%. Conclusion: The temporal association between novel coronavirus disease 2019 (COVID-19) onset and Kawasaki-like disease and MIS-C suggests a causal link. Both syndromes have similar cascades of symptoms and hyperinflammation, which likely explain their response to the same immunomodulatory agents. However, it is unclear yet why some children appear more susceptible to develop MIS-C.

Jordanian experience: The internet pharmacy drug delivery platform during the COVID-19.

The present study aimed to see how well the newly designed internet hospital drug delivery platform model worked in the pharmacy department during the COVID-19 pandemic to make it easier for patients to get their prescribed drugs during the home quarantine. Methods: The internet hospital drug delivery platform was designed and activated by the pharmacy department in collaboration with the information technology department. The pharmacy department, in partnership with the information technology department, built and launched the internet hospital drug delivery platform (IHDD) immediately after the Jordanian government declared a full lockdown. Results: During the quarantine, a total of 5994 prescriptions, including 28494 medications, were delivered to 4853 patients. The majority of the patients (n = 1835; 37.8%) were aged 60 to 74.Nearly three quarters (4722; 78.8%) of the patients were from Amman, the capital of Jordan, and the top five online prescription departments were cardiology (n = 1737, 31.6%), endocrinology (n = 624, 11.4%), nephrology (n = 557, 10.1%), respiratory (n = 462, 8.4%), and neurology (n = 412, 7.5%). Conclusion: The IHDD platform was found to be efficient and convenient because it handled the challenge of precisely delivering medications to patients on time. To meet the pandemic's challenge, the pharmacy department has extended its inventive powers. In addition to safeguarding the environment, health technology was used to provide a coordinated, systematic program for the administration of medications. The pharmacy department, in partnership with the information technology department, built and deployed the internet hospital drug distribution infrastructure shortly after Jordan's government proclaimed a full lockdown. During the quarantine, a total of 5994 prescriptions, including 28494 medications, were delivered to 4853 patients. The majority of the patients (n = 1835; 37.8%) were between the ages of 60 and 74.Nearly three quarters (4722; 78.8%) of the patients were from Amman, the capital of Jordan, and the top five online prescription departments were cardiology (n = 1737, 31.6%), endocrinology (n = 624, 11.4%), nephrology (n = 557, 10.1%), respiratory (n = 462, 8.4%), and urology (n = 412, 7.5%). The pharmacy department has expanded its capabilities creatively to face the challenge posed by the pandemic. Health technology was utilized to ensure a coordinated, systematic program for the delivery of medications, in addition to preserving the safety of the dedicated staff.

Factors affecting the public's knowledge about COVID-19 vaccines and the influence of knowledge on their decision to get vaccinated.

OBJECTIVE: An analysis was conducted to assess the factors affecting the public's knowledge about coronavirus disease (COVID-19) vaccines and the influence of that knowledge on their decision to get vaccinated. STUDY DESIGN: Cross-sectional survey. METHODS: An online, self-administered questionnaire was instrumentalized to assess the factors affecting the Jordanian public's knowledge about COVID-19 vaccines and the influence of that knowledge on their decision to get vaccinated. A multiple linear regression analysis was carried out to determine the variables that affected the participants' knowledge score regarding COVID-19 vaccines. The Mann-Whitney U test was used to evaluate the differences in knowledge scores among different groups. P < 0.05 was considered statistically significant. RESULTS: Only 45.9% of the 468 participants reported being willing to receive the vaccine, and only 38.5% (n = 180) had registered on the Ministry of Health platform to get vaccinated. Moreover, very few of them (26/468, 5.6%) had received the vaccine. The participants showed inadequate knowledge, with a median knowledge score of 4 out of 8 (interquartile range = 4). The linear regression analysis showed that participants aged above 45 years, those with bachelor's or graduate degrees, and those with medical-related degrees had higher knowledge scores regarding COVID-19 vaccines than the others (P < 0.001). Participants who were willing to receive the vaccine, those who had registered to receive the vaccine, and those who had got vaccinated had higher knowledge scores than the others (P < 0.001 for all). CONCLUSION: This cross-sectional analysis indicated that urgent education is needed to improve the public's knowledge and awareness about the COVID-19 vaccine to reduce the adverse impact of lack of knowledge on decision making for the COVID-19 vaccination.

Prevalence of potentially inappropriate prescribing in older adults in Jordan: Application of the STOPP criteria.

OBJECTIVES: To measure the prevalence of cases of potentially inappropriate prescribing (PIP) for older patients and to identify the risk factors for identified cases of PIP. METHODS: STOPP criteria version 2 were used for identifying cases of PIP for older patients (>65 years) who were admitted to a tertiary hospital in Jordan over a period of 18 months. Data were collected by prospectively reviewing the clinical and prescription records of included patients. Descriptive analysis, univariate analysis and multiple linear regression were used to analyse the results. RESULTS: Upon admission, during hospitalisation and on discharge, 144, 182 and 156 cases of PIP were identified, respectively. There was a statistically significant association between the number of prescribed medications and cases of PIP during the hospital journey (P < .05). CONCLUSION: Inappropriate prescribing of medications is highly prevalent among older patients. Application of validated (STOPP) criteria can help to detect and direct development of interventions to prevent PIP occurrence among older patients.

Antimicrobial Consumption and Resistance in a Tertiary Care Hospital in Jordan: Results of an Internet-Based Global Point Prevalence Survey.

Background: The Global Point Prevalence Survey (Global-PPS) provides a standardised method to conduct surveillance of antimicrobial prescribing and resistance at hospital level. The aim of the present study was to assess antimicrobial consumption and resistance in a Jordan teaching hospital as part of the Global-PPS network. Methods: Detailed antimicrobial prescription data were collected according to the Global Point Prevalence Survey protocol. The internet-based survey included all inpatients present at 8:00 am on a specific day in June-July 2018. Resistance data were based on microbiological results available on the day of the PPS. Results: Data were collected for 380 patients admitted to adult wards, 72 admitted children, and 36 admitted neonates. The overall prevalence of antimicrobial use in adult, paediatric, and neonatal wards was 45.3%, 30.6%, and 22.2% respectively. Overall, 36 patients (7.4%) were treated for at least one healthcare-associated infection (HAI). The most frequent reason for antimicrobial treatment was pneumonia. Cephalosporins and carbapenems were most frequent prescribed among adult (50.6%) and paediatric/neonatal wards (39.6%). Overall resistance rates among patients treated for a community or healthcare-associated infection was high (26.0%). Analysis of antibiotic quality indicators by activity revealed good adherence to treatment guidelines but poor documentation of the reason for prescription and a stop/review date in the notes. Conclusion: The present study has established baseline data in a teaching hospital regarding the quantity and quality of prescribed antibiotics in the hospital. The study should encourage the establishment of tailor-made antimicrobial stewardship interventions and support educational programs to enhance appropriate antibiotic prescribing.