1.
J Med Chem
; 55(1): 489-502, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22098494
RESUMO
Cyclic hydroxyamidines were designed and validated as isosteric replacements of the amide functionality. Compounds with these structural motifs were found to be metabolically stable and to possess highly desirable pharmacokinetic profiles. These designs were applied in the identification of γ-secretase modulators leading to highly efficacious agents for reduction of central nervous system Aß(42) in various animal models.