RESUMO
The effects of different doses of Asu(1,7) eel-calcitonin, peripherally injected, on gastric secretion were studied in conscious Brattleboro rats, which are genetically deficient in vasopressin. Moreover, we evaluated the activity of this analogue on gastric ulcer formation by restraint stress. We found that 5 IU/kg Asu(1,7) eel-calcitonin decreased gastric secretion and inhibited the development of stress-induced ulcers in Brattleboro rats. These data suggest that vasopressin does not play a role in the gastrointestinal activity of Asu(1,7) eel-calcitonin.
Assuntos
Calcitonina/análogos & derivados , Mucosa Gástrica/metabolismo , Úlcera Gástrica/prevenção & controle , Estresse Fisiológico/complicações , Vasopressinas/deficiência , Animais , Calcitonina/uso terapêutico , Enguias , Heterozigoto , Homozigoto , Injeções Intravenosas , Masculino , Ratos , Ratos Brattleboro , Valores de Referência , Úlcera Gástrica/etiologiaRESUMO
The effects of different doses of (Asu1,7) eel-calcitonin, iv injected, on gastric secretion were studied in conscious rats with pyloric occlusion. Moreover, we evaluated the activity of this analogue on gastric ulcer formation by restraint stress. It was found that 2.5 or 5 Ul/kg (Asu1,7) eel-calcitonin decreased gastric acid secretion and inhibited the development of stress-induced ulcers in rats. In the isolated rat stomach the peptide at the concentrations of 1 nM to 1 microM did not modify acetylcholine, histamine or 5-hydroxytriptamine-induced contractions. These results suggest that this peripheral activity of (Asu1,7) eel-calcitonin does not involve a direct interference with cholinergic, histaminergic or serotonergic pathways at gastric level.
Assuntos
Calcitonina/análogos & derivados , Estômago/efeitos dos fármacos , Estresse Fisiológico/fisiopatologia , Animais , Calcitonina/farmacologia , Ácido Gástrico/metabolismo , Suco Gástrico/metabolismo , Técnicas In Vitro , Masculino , Contração Muscular/efeitos dos fármacos , Músculo Liso/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Restrição Física , Úlcera Gástrica/etiologia , Úlcera Gástrica/prevenção & controleRESUMO
Neuroendocrine and behavioral effects following an acute or chronic treatment with the calcium antagonist, flunarizine, have been studied in young and old rats. Both in young and old rats, acute administration of flunarizine (2 mg/kg) failed to modify plasma prolactin (PRL) levels, as measured at 8.00 a.m., 4.00 p.m. and 12.00 p.m. A chronic treatment with flunarizine (0.5 mg/kg/day, for 20 days) in young rats was followed by a relevant, albeit statistically not significant, increase in plasma PRL levels, as measured at 8.00 a.m. and 4.00 p.m., and by a significant decrease at 12.00 p.m. A shift of nocturnal peak of plasma PRL levels from 12.00 p.m. to 4.00 a.m. was observed in these animals. A chronic treatment with flunarizine in old rats was followed by a significant increase in plasma PRL levels, as measured at 12.00 p.m. The acquisition of active avoidance behavior was studied in a shuttle-box test. Acute administration of flunarizine failed to change the performance of young and old rats in acquiring the behavioral response, as measured by the total number of conditioned avoidance responses (CARs) and the percentage of learners. When flunarizine was administered chronically, a decrease in CARs and learners was observed both in young and old rats. This was accompanied by a significant increase in the percentage of animals that froze during the acquisition session. No significant effect was found in young and old rats tested in a "despair" test after a chronic treatment with flunarizine.
Assuntos
Comportamento Animal/efeitos dos fármacos , Bloqueadores dos Canais de Cálcio/farmacologia , Cinarizina/farmacologia , Piperazinas/farmacologia , Fatores Etários , Animais , Aprendizagem da Esquiva/efeitos dos fármacos , Cinarizina/análogos & derivados , Flunarizina , Masculino , Prolactina/sangue , Ratos , Ratos EndogâmicosRESUMO
A proposito de dos observaciones de tricorrexis nudosa, se hace una breve referencia a los antecedentes historicos de la enfermedad y a sus formas clinicas: congenita y adquirida. Dado que la forma adquirida de tricorrexis nudosa es resultado de traumas fisicos e quimicos, con o sin diatesis sistemica, se presume que pueda incrementar su aparicion debido al avance de la cosmetica capilar y la aceptacion de la misma por ambos sexos
Assuntos
Adulto , Humanos , Masculino , Dermatoses do Couro CabeludoRESUMO
A proposito de dos observaciones de tricorrexis nudosa, se hace una breve referencia a los antecedentes historicos de la enfermedad y a sus formas clinicas: congenita y adquirida. Dado que la forma adquirida de tricorrexis nudosa es resultado de traumas fisicos e quimicos, con o sin diatesis sistemica, se presume que pueda incrementar su aparicion debido al avance de la cosmetica capilar y la aceptacion de la misma por ambos sexos
Assuntos
Adulto , Humanos , Masculino , Dermatoses do Couro CabeludoAssuntos
Eczema/etiologia , Hipergamaglobulinemia/complicações , Imunoglobulina E/análise , Tatuagem/efeitos adversos , Adulto , Doença Crônica , Dermatite Atópica/diagnóstico , Diagnóstico Diferencial , Eczema/imunologia , Humanos , Hipergamaglobulinemia/diagnóstico , Masculino , Dermatopatias Infecciosas/etiologia , SíndromeRESUMO
Se presentan cinco casos de Mastocitosis cutanea tratados con Ketotifeno. Los autores hacen consideraciones acerca del mecanismo de accion de la droga y destacan los aspectos mas importantes del tratamiento, que conduciran a futuras investigaciones
Assuntos
Adolescente , Idoso , Humanos , Masculino , Feminino , Cetotifeno , Urticaria PigmentosaRESUMO
Se presentan cinco casos de Mastocitosis cutanea tratados con Ketotifeno. Los autores hacen consideraciones acerca del mecanismo de accion de la droga y destacan los aspectos mas importantes del tratamiento, que conduciran a futuras investigaciones
