Inhaled mycotoxins lead to acute renal failure.

Mysterious deaths of archeologists after opening Egyptian tombs have been suspected, but never proved, to be secondary to inhalation of mycotoxin. We observed a case of acute renal failure (ARF) due to inhalation of ochratoxin A produced by a mould of the species Aspergillus ochraceus. After working 8 h in a granary closed for several months, a farmer and his wife suffered respiratory distress; the woman developed non-oliguric ARF and biopsy revealed tubulonecrosis. A strain of Aspergillus ochraceus producing ochratoxin was isolated from the wheat.

Hongos aislados del plumaje y excremento de gallinas en una industria avicola de Monferrato, Pavia Italia / Fungi isolated from feathers and faeces of hens in an avian industry of Monferrato, Pavia Italy

Mediante cultivos en sustratos queratínicos, diluciones en PDA y un medio selectivo para Cryptococcus neoformans, se evaluó durante 2 períodos estacionales en una industria avicola, la micota presente en el plumaje y excrementos de gallinas sanas y enfermas, con la finalidad de evaluar la frecuencia de presencia de algunos hongos considerados potencialmente patógenos o toxicogénicos. En el plumaje de las aves sanas predominaron Aspergillus fumigatus, A. niger, Penicillium glabrum, mientras en sus excrementos Candida famata, C. guilliermondi. Cryptococcus laurentii, Mucor hiemalis y M. racemosus. El plumaje de las aves enfermas presentó una mayor diversidad de especies, dominando: A. niger, P. purpurogenum, Fusarium equiseti, Chrysosporium Keratinophilum, Chry. indicum, mientras en los excrementos, A. flavus, A. clavatus, A. fumigatus, M. hiemalis y M. racemosus, Candida albicans, C. pseudotropicalis y Cryptococcus laurentii. Cryptococcus neoformans var. neoformans, se aisló con baja frecuencia en las heces. Estas aves y su habitat, constituyen un ambiente vinculado a la ecología de algunos hongos filamentosos y levaduriformes con capacidad toxicogénica o invasiva, representando un reservorio y una fuente de infección para las aves y el personal de estas industrias

Acute renal failure from inhalation of mycotoxins.

Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending 8 h in a granary which had been closed for several months, a farmer and his wife suffered temporary respiratory distress; 24 h later, the woman developed nonoliguric ARF and biopsy revealed tubulonecrosis which healed in 24 days. Toxic substances were not found, but a strain of A. ochraceus producing ochratoxin was isolated from the wheat.

Keratinophilic fungi isolated from soil of Italian parks in the province of Pavia.

Soil samples collected from 9 parks in the Italian province of Pavia were baited with hair and feathers for the isolation of keratinophilic fungi. The dominant species were the teleomorphs Arthroderma gypsea, A. uncinatum, Ctenomyces serratus and Aphanoascus fulvescens with their anamorphs. Among the other species isolated, Amauroascus mutatus, Gymnascella dankaliensis, Gymnoascus intermedius and Gymnoascus reessii were recorded. The distribution of these fungi is discussed and related to previous records.

Superficial mycoses in Italy.

A total of 1244 cases suspected of superficial mycoses were analysed in a period of 12 months in Italy. Dermatophytoses were found in 62.4%; the other common disease was Pityriasis versicolor (44.1%)., The predominant species Epidermophyton floccosum (34,2%) was strikingly high in relation to other statistics; this species was commonest in tinea cruris. Among the other dermatophytes M. canis was predominant (31.3%) commonest in tinea corporis, followed by T. mentagrophytes (17,8%) and T. rubrum (10,3%). A high rate of yeasts was found in tinea manum (81.6%) and tinea pedis (47.7%). ?

Multicentre clinical study with tolciclate in the local treatment of skin mycoses in 1083 patients.

A multicentre clinical trial with tolciclate was carried out in Italy on 1083 patients suffering from skin mycoses (tinea corporis, tinea cruris, tinea pedis, tinea manuum and pityriasis versicolor). Both preparations (1% cream and lotion) showed a good activity evaluated weekly by clinical examinations and mycological assessments, i.e. culture for tineas and microscopy for pityriasis versicolor. Favourable clinical results ranged from 83% to 97% according to diagnoses. Cultural or microscopic conversions obtained in a mean time of about 2 weeks varied from 70% to 91%. Mycological relapses a month after the end of treatment were seen in 6.5% of cases examined. Adverse reactions were observed in 5.6% of patients but the treatment was discontinued only in 2.6%.