RESUMO
An efficient method was developed for the synthesis of substituted aryl-fused pyrazolooxazepines from ortho-O-propargyl aryl pyrazoles by gold catalysis. In this organic transformation a new C-N bond was formed regioselectively via 7-exo-dig cyclization. Moderate to good yields of aryl-fused pyrazolooxazepine derivatives were obtained with significant molecular complexity in one-pot.
RESUMO
An efficient gold-catalyzed synthesis of substituted 3-methylene-3,4-dihydrobenzo[b]oxepinones from ortho-O-propargyl substituted aryl enaminones has been achieved. In this transformation a new C-C bond formation occurred regioselectively via 7-exo-dig cyclization. Benzooxepinone derivatives were obtained in good to excellent yields in a one-pot synthesis at ambient temperature.
RESUMO
An efficient gold-catalyzed intramolecular cyclization of ortho-O-propargyl-1-one substituted arylaldehydes has been achieved for the generation of substituted aroylbenzo[b]oxepin-3-one derivatives in moderate to good yields. This synthetic transformation proceeds via gold-catalysed oxidation of the internal alkyne moiety followed by an intramolecular condensation leading to seven-membered oxacycles.
RESUMO
Synthesis of substituted 1,2-dihydropyridinones is described in a one pot reaction of ß-enaminones and acetylene dicarboxylates where new C-C and C-N bonds were formed. The title compounds were obtained in moderate to good yields.
Assuntos
Acetileno/química , Aminas/química , Ácidos Carboxílicos/química , Piridinas/química , Piridonas/química , Carbono/química , Catálise , Cristalografia por Raios X , Desenho de Fármacos , Ésteres/química , Humanos , Modelos Químicos , Estrutura Molecular , Nitrogênio/química , Solventes/química , TemperaturaRESUMO
A gold(I) catalysed reaction between N-propargylic ß-enaminones and arynes was developed to access 3-methylene-1-pyrrolines. The title compounds were obtained in 57-78% yields. This reaction is useful for the generation of substituted 1-pyrrolines exhibiting significant molecular complexity.
