Dosimetric end-to-end tests in a national audit of 3D conformal radiotherapy.

BACKGROUND AND PURPOSE: Independent dosimetry audits improve quality and safety of radiation therapy. This work reports on design and findings of a comprehensive 3D conformal radiotherapy (3D-CRT) Level III audit. MATERIALS AND METHODS: The audit was conducted as onsite audit using an anthropomorphic thorax phantom in an end-to-end test by the Australian Clinical Dosimetry Service (ACDS). Absolute dose point measurements were performed with Farmer-type ionization chambers. The audited treatment plans included open and half blocked fields, wedges and lung inhomogeneities. Audit results were determined as Pass Optimal Level (deviations within 3.3%), Pass Action Level (greater than 3.3% but within 5%) and Out of Tolerance (beyond 5%), as well as Reported Not Scored (RNS). The audit has been performed between July 2012 and January 2018 on 94 occasions, covering approximately 90% of all Australian facilities. RESULTS: The audit pass rate was 87% (53% optimal). Fifty recommendations were given, mainly related to planning system commissioning. Dose overestimation behind low density inhomogeneities by the analytical anisotropic algorithm (AAA) was identified across facilities and found to extend to beam setups which resemble a typical breast cancer treatment beam placement. RNS measurements inside lung showed a variation in the opposite direction: AAA under-dosed a target beyond lung and over-dosed the lung upstream and downstream of the target. Results also highlighted shortcomings of some superposition and convolution algorithms in modelling large angle wedges. CONCLUSIONS: This audit showed that 3D-CRT dosimetry audits remain relevant and can identify fundamental global and local problems that also affect advanced treatments.

SPECT/CT bone imaging after hip resurfacing arthroplasty: is it feasible to use CT attenuation correction in the presence of metal implants?

BACKGROUND: In hip resurfacing arthroplasty a metal implant (prosthesis) is used to resurface the patient's native femoral head. The assessment of bone function around the implant is important in evaluating any subsequent complications. The use of bone single photon emission computed tomography/computed tomography (SPECT/CT) imaging may enhance this evaluation. OBJECTIVES: The primary objective of this study was to ascertain whether SPECT/CT imaging is feasible in the presence of the metal implant. A secondary objective was to deduce the impact attenuation correction has on the detected counts originating from bone covered by the metal implant. METHODS: A phantom was constructed to allow assessment of counts obtained from a point source (PS) imaged in the vicinity of a hip resurfacing implant. Three implant cup sizes (4, 8 and 10) were assessed and images acquired with a PS positioned adjacent to the implant pin and under the cup. Multiple acquisitions were undertaken both with and without surrounding soft tissue equivalent material. The images were analysed with and without attenuation correction and the recovered counts compared with that ofa PS imaged in free space (control). RESULTS: Attenuation-corrected counts did not vary significantly with cup size (P=0.427), PS position (P=0.999), presence of soft tissue equivalent material (P=0.193) or a combination of PS position and soft tissue(P=0.193). The attenuation-corrected counts recovered from a PS (soft tissue equivalent material present) showed an overestimation, compared with the control, both when positioned adjacent to the pin and under the cup; mean 8% (4-16%) and 4% (1-6%), respectively. CONCLUSION: The results of the study suggest that the application of the attenuation correction technique is applicable to bone SPECT/CT images of the femoral head-neck junction acquired in the presence of a hip resurfacing implant.

Planning with intensity-modulated radiotherapy and tomotherapy to modulate dose across breast to reflect recurrence risk (IMPORT High trial).

PURPOSE: To establish planning solutions for a concomitant three-level radiation dose distribution to the breast using linear accelerator- or tomotherapy-based intensity-modulated radiotherapy (IMRT), for the U.K. Intensity Modulated and Partial Organ (IMPORT) High trial. METHODS AND MATERIALS: Computed tomography data sets for 9 patients undergoing breast conservation surgery with implanted tumor bed gold markers were used to prepare three-level dose distributions encompassing the whole breast (36 Gy), partial breast (40 Gy), and tumor bed boost (48 or 53 Gy) treated concomitantly in 15 fractions within 3 weeks. Forward and inverse planned IMRT and tomotherapy were investigated as solutions. A standard electron field was compared with a photon field arrangement encompassing the tumor bed boost volume. The out-of-field doses were measured for all methods. RESULTS: Dose-volume constraints of volume >90% receiving 32.4 Gy and volume >95% receiving 50.4 Gy for the whole breast and tumor bed were achieved. The constraint of volume >90% receiving 36 Gy for the partial breast was fulfilled in the inverse IMRT and tomotherapy plans and in 7 of 9 cases of a forward planned IMRT distribution. An electron boost to the tumor bed was inadequate in 8 of 9 cases. The IMRT methods delivered a greater whole body dose than the standard breast tangents. A contralateral lung volume >2.5 Gy was increased in the inverse IMRT and tomotherapy plans, although it did not exceed the constraint. CONCLUSION: We have demonstrated a set of widely applicable solutions that fulfilled the stringent clinical trial requirements for the delivery of a concomitant three-level dose distribution to the breast.