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BACKGROUND: Predicting diabetic retinopathy (DR) progression could enable individualised screening with prompt referral for high-risk individuals for sight-saving treatment, whilst reducing screening burden for low-risk individuals. We developed and validated deep learning systems (DLS) that predict 1, 2 and 3 year emergent referable DR and maculopathy using risk factor characteristics (tabular DLS), colour fundal photographs (image DLS) or both (multimodal DLS). METHODS: From 162,339 development-set eyes from south-east London (UK) diabetic eye screening programme (DESP), 110,837 had eligible longitudinal data, with the remaining 51,502 used for pretraining. Internal and external (Birmingham DESP, UK) test datasets included 27,996, and 6928 eyes respectively. RESULTS: Internal multimodal DLS emergent referable DR, maculopathy or either area-under-the receiver operating characteristic (AUROC) were 0.95 (95% CI: 0.92-0.98), 0.84 (0.82-0.86), 0.85 (0.83-0.87) for 1 year, 0.92 (0.87-0.96), 0.84 (0.82-0.87), 0.85 (0.82-0.87) for 2 years, and 0.85 (0.80-0.90), 0.79 (0.76-0.82), 0.79 (0.76-0.82) for 3 years. External multimodal DLS emergent referable DR, maculopathy or either AUROC were 0.93 (0.88-0.97), 0.85 (0.80-0.89), 0.85 (0.76-0.85) for 1 year, 0.93 (0.89-0.97), 0.79 (0.74-0.84), 0.80 (0.76-0.85) for 2 years, and 0.91 (0.84-0.98), 0.79 (0.74-0.83), 0.79 (0.74-0.84) for 3 years. CONCLUSIONS: Multimodal and image DLS performance is significantly better than tabular DLS at all intervals. DLS accurately predict 1, 2 and 3 year emergent referable DR and referable maculopathy using colour fundal photographs, with additional risk factor characteristics conferring improvements in prognostic performance. Proposed DLS are a step towards individualised risk-based screening, whereby AI-assistance allows high-risk individuals to be closely monitored while reducing screening burden for low-risk individuals.
Diabetic retinopathy (DR) is a disease where the light-sensing layer at the back of the eye (retina) becomes damaged by raised blood sugar levels. It affects around one in three of the 463 million people with diabetes worldwide and is a leading cause of acquired vision loss in working-age adults. In this study, we developed computer-based models to predict when DR would reach a stage where vision could be threatened up to 3-years in the future. Our study shows that this system can accurately predict sight-threatening DR in patients with diabetes. This could mean fewer unnecessary visits for individuals at low-risk of DR progression, but closer monitoring and potentially earlier treatment for individuals at high-risk of DR progression, which could reduce the risk of vision loss.
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Background/Aim: has shown that sketching while narrating facilitates the elicitation of information and verbal veracity cues in single interviews. We examined if these effects are retained when suspects are shown their sketch after one week in a repeated interview. Method: Participants (N = 173) completed a mock mission and then told the truth or lied about it in an immediate interview (interview 1). Participants either verbally reported the mission (Free recall condition) or sketched it while describing what they were sketching (sketch condition). After one week, all participants were asked for a free recall without sketching (interview 2). Half of the participants in the Sketch condition had access to their sketch while they verbally reported the event whereas the remaining half did not access the sketch. Results: Truth tellers provided more information than lie tellers in both interviews, and sketching elicited more information than a free recall but only in Interview 1. Participants who had access to their sketch in interview 2 repeated more information than those who did not have access, but accessing the sketch did not have an effect on veracity cues. Conclusions: Thus, sketching enhanced the elicitation of information in Interview 1 and access to the sketch in interview 2 seemed helpful for recalling previously reported information. (AU)
Antecedentes/objetivo: La investigación ha revelado que el uso de esquemas mientras se lleva a cabo una narración facilita la obtención de información y de indicios verbales de veracidad en una entrevista. Analizamos si estos efectos se mantienen cuando se somete a los sospechosos a su esquema de los hechos en entrevistas repetidas (una semana después). Método: Los participantes (N = 173) completaron una misión simulada y luego contaban la verdad o mentían sobre la misma en una entrevista realizada de modo inmediato (entrevista 1). Los participantes o bien referían verbalmente la misión (condición de recuerdo libre) o la esquematizaban (condición de esquematización). Después de una semana se pidió a todos los participantes un recuerdo libre sin esquematizar (entrevista 2). La mitad de los participantes de la condición de esquematización podían acceder a su esquema mientras referían verbalmente el suceso y la otra mitad no tenía acceso al esquema. Resultados: Los que contaban la verdad daban más información que los que mentían en ambas entrevistas y el esquema facilitaba más información que el recuerdo libre aunque tan solo en la entrevista 1. Aquellos participantes que tenían acceso a su esquema en la entrevista 2 repetían más información que quienes no tenían acceso, aunque el acceso no tenía efecto alguno en indicios de veracidad. Conclusiones: En conclusión, los esquemas incrementaron la obtención de información en la entrevista 1 y el acceso al esquema en la entrevista 2 resultó útil para recordar la información relatada previamente. (AU)
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Humanos , Detecção de Mentiras/psicologia , Entrevista Psicológica , Entrevistas como Assunto/métodosRESUMO
Objective: While the use of negative pressure wound therapy (NPWT) with reticulated open cell foam (ROCF) is well established, the characteristics of ROCF do not allow for extended-wear use. There is the potential for dressing tissue ingrowth if left in place for greater than the recommended 2-3 days. An easy to use, novel peel and place dressing has been designed for extended wear with the wound management advantages of ROCF while alleviating the challenges of tissue ingrowth. Approach: Paraspinal, full-thickness or deep muscle excisional wounds were created in 11 and 2 swine, respectively, dressings applied with continuous negative pressure at -125 mmHg, and dressings changed weekly. Full-thickness excisional wounds were treated for 13 days and deep muscle wounds for 35 days. Wound dimensions were assessed. Granulation tissue thickness and re-epithelialization were measured via digital morphometry. Tissue quality, fibrinous material prevalence, and dressing removal peel force were analyzed. Results: The peel and place dressing substantially reduces dressing tissue ingrowth, is easy to remove with markedly low dressing peel force and promotes more granulation tissue at day 13 than ROCF with an interface layer. The extended-wear peel and place dressing, when applied to deep muscle wounds with weekly dressing changes, was applied for a total of 35 days. Successful wound closure was evident without any negative impact on wound healing. Innovation: This study assessed the wound management capabilities of an extended-wear peel and place NPWT dressing used until wound closure. Conclusion: The peel and place dressing is a suitable extended-wear NPWT dressing.
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Modelos Animais de Doenças , Tratamento de Ferimentos com Pressão Negativa , Cicatrização , Animais , Tratamento de Ferimentos com Pressão Negativa/métodos , Suínos , Bandagens , Tecido de Granulação/patologia , Reepitelização , FemininoRESUMO
BACKGROUND/OBJECTIVES: Currently, all pregnant women with diabetes are asked to attend screening at least twice during pregnancy, even if no retinopathy is detected in early pregnancy. We hypothesise that for women with no diabetic retinopathy in early pregnancy, the frequency of retinal screening may be safely reduced. SUBJECTS/METHODS: In this retrospective cohort study, data for 4718 pregnant women attending one of three UK Diabetic Eye Screening (DES) Programmes between July 2011 and October 2019 was extracted. The women's UK DES grades at 13 weeks gestation (early pregnancy) and 28 weeks gestation (late pregnancy) were recorded. Descriptive statistics were used to report baseline data. Ordered logistic regression was used to control for covariates, such as age, ethnicity, diabetes duration, and diabetes type. RESULTS: Of the women with grades recorded for both early and late pregnancy, a total of 3085 (65.39%) women had no retinopathy in early pregnancy, and 2306 (74.7%) of these women did not develop any retinopathy by 28 weeks. The number of women without retinopathy in early pregnancy who developed referable retinopathy was 14 (0.45%), none of whom required treatment. Diabetic Retinopathy in early pregnancy remained a significant predictor of DES grade in late pregnancy when covariates of Age, Ethnicity, and Diabetes Type were controlled for (P < 0.001). CONCLUSIONS: In summary, this study has demonstrated that the burden of managing diabetes for pregnant mothers may be safely reduced by limiting the number of diabetic eye screening appointments in women who have no retinal changes in early pregnancy. Screening of women with retinopathy in early pregnancy should continue in line with current UK guidance.
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Diabetes Mellitus , Retinopatia Diabética , Feminino , Humanos , Gravidez , Masculino , Retinopatia Diabética/diagnóstico , Gestantes , Estudos Retrospectivos , Programas de Rastreamento , Reino Unido/epidemiologiaRESUMO
A man in his 60s presented for his medical retina clinic appointment, reporting increasing shortness of breath, aches and pains, and increasing insulin requirements during a difficult early lockdown. Wide-field colour fundus imaging (Optos Optomap) and an optical coherence tomography scan (Heidelberg Spectralis) revealed whitened and enlarged hyper-reflective vessels. Retinal colour photography also confirmed a creamy white discolouration of the vessels, which prompted the team to order a lipid profile. The profile showed a raised cholesterol level of 17.5 mmol/L (normal: <4mmol/L) and a marked elevated triglyceride level of 38.41 mmol/L (normal: <1.7 mmol/L).The clinical picture, alongside the biochemical results, suggested a diagnosis of secondary lipaemia retinalis due to poorly controlled diabetes. With aggressive treatment, the patient's biochemistry and vessels returned to baseline.This rare condition should be taken as an indicator of a potential underlying life-threatening medical condition and the role an ophthalmologist has in initiating potential lifesaving intervention.
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Diabetes Mellitus Tipo 2 , Hiperlipidemias , Doenças Retinianas , Masculino , Humanos , Diabetes Mellitus Tipo 2/complicações , Doenças Retinianas/diagnóstico , Hiperlipidemias/complicações , Retina , Fundo de Olho , Tomografia de Coerência Óptica/métodosRESUMO
PURPOSE: To determine associations between deprivation using the Index of Multiple Deprivation (IMD and individual IMD subdomains) with incident referable diabetic retinopathy/maculopathy (termed rDR). METHODS: Anonymised demographic and screening data collected by the South-East London Diabetic Eye Screening Programme were extracted from September 2013 to December 2019. Multivariable Cox proportional models were used to explore the association between the IMD, IMD subdomains and rDR. RESULTS: From 118 508 people with diabetes who attended during the study period, 88 910 (75%) were eligible. The mean (± SD) age was 59.6 (±14.7) years; 53.94% were male, 52.58% identified as white, 94.28% had type 2 diabetes and the average duration of diabetes was 5.81 (±6.9) years; rDR occurred in 7113 patients (8.00%). Known risk factors of younger age, Black ethnicity, type 2 diabetes, more severe baseline DR and diabetes duration conferred a higher risk of incident rDR. After adjusting for these known risk factors, the multivariable analysis did not show a significant association between IMD (decile 1 vs decile 10) and rDR (HR: 1.08, 95% CI: 0.87 to 1.34, p=0.511). However, high deprivation (decile 1) in three IMD subdomains was associated with rDR, namely living environment (HR: 1.64, 95% CI: 1.12 to 2.41, p=0.011), education skills (HR: 1.64, 95% CI: 1.12 to 2.41, p=0.011) and income (HR: 1.19, 95% CI: 1.02 to 1.38, p=0.024). CONCLUSION: IMD subdomains allow for the detection of associations between aspects of deprivation and rDR, which may be missed when using the aggregate IMD. The generalisation of these findings outside the UK population requires corroboration internationally.
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OBJECTIVE: There is limited information on the effect of ethnicity on the development of referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. This study describes the risk factors for STDR in a diverse cohort of people with type 1 diabetes attending a regional diabetes eye screening service. RESEARCH DESIGN AND METHODS: Clinical and digital retinal imaging data from 1,876 people with type 1 diabetes (50% women, 72.1% Caucasian, 17.3% African Caribbean, 2.9% Asian, and 7.6% other) with no retinopathy at baseline, attending surveillance eye screening were reviewed. Referable STDR was defined as the presence of any moderate to severe nonproliferative or preproliferative diabetic retinopathy or proliferative diabetic retinopathy or maculopathy in either eye as per U.K. National Diabetic Eye Screening criteria. Median follow-up was 6 years. RESULTS: The median (interquartile range) age of the cohort was 29 (21, 41) years. Of the cohort of 1,876 people, 359 (19%) developed STDR. People who developed STDR had higher baseline HbA1c, raised systolic blood pressure (SBP), longer diabetes duration, and were more often of African Caribbean origin (24% vs. 15.6%; P < 0.05 for all). In multivariable Cox regression analyses, African Caribbean ethnicity (hazard ratio [HR] 1.39, 95% CI 1.09-1.78, P = 0.009), baseline SBP (HR 1.01, 95% CI 1.00-1.01, P = 0.033), and baseline HbA1c (HR 1.01, 95% CI 1.00-1.01, P = 0.0001) emerged as independent risk factors for STDR. CONCLUSIONS: We observed that people with type 1 diabetes of African Caribbean ethnicity are at significantly greater risk of STDR. Further research is required to understand the mechanisms that explain this novel observation.
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Diabetes Mellitus Tipo 1 , Retinopatia Diabética , Humanos , Feminino , Masculino , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/epidemiologia , Retinopatia Diabética/diagnóstico , Hemoglobinas Glicadas , Etnicidade , Fatores de RiscoRESUMO
BACKGROUND: Sketching while narrating is an effective interview technique for eliciting information and cues to deceit. The current research examined the effects of introducing a Model Sketch in investigative interviews andis pre-registered on https://osf.io/kz9mc (accessed on 18 January 2022). METHODS: Participants (N = 163) completed a mock mission and were asked to tell the truth or to lie about it in an interview. In Phase 1 of the interview, participants provided either a free recall (control condition), sketched and narrated with exposure to a Model Sketch (Model Sketch-present condition), or sketched and narrated without exposure to a Model Sketch (Model Sketch-absent condition). In Phase 2, all participants provided a free recall without sketching. RESULTS: Truth tellers reported significantly more information than lie tellers. The Model Sketch elicited more location details than a Free recall in Phase 1 and more veracity differences than the other Modality conditions in Phase 2. CONCLUSION: The Model Sketch seems to enhance the elicitation of information and to have carryover veracity effects in a follow-up free recall.
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Diabetic retinopathy (DR) screening images are heterogeneous and contain undesirable non-retinal, incorrect field and ungradable samples which require curation, a laborious task to perform manually. We developed and validated single and multi-output laterality, retinal presence, retinal field and gradability classification deep learning (DL) models for automated curation. The internal dataset comprised of 7743 images from DR screening (UK) with 1479 external test images (Portugal and Paraguay). Internal vs external multi-output laterality AUROC were right (0.994 vs 0.905), left (0.994 vs 0.911) and unidentifiable (0.996 vs 0.680). Retinal presence AUROC were (1.000 vs 1.000). Retinal field AUROC were macula (0.994 vs 0.955), nasal (0.995 vs 0.962) and other retinal field (0.997 vs 0.944). Gradability AUROC were (0.985 vs 0.918). DL effectively detects laterality, retinal presence, retinal field and gradability of DR screening images with generalisation between centres and populations. DL models could be used for automated image curation within DR screening.
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Aprendizado Profundo , Diabetes Mellitus , Retinopatia Diabética , Macula Lutea , Retinopatia Diabética/diagnóstico por imagem , Humanos , Programas de Rastreamento/métodos , Retina/diagnóstico por imagemRESUMO
Background: In two experiments we examined whether lie tellers, after reading articles about the Model Statement interview tool and/or about the verbal cues complications, common knowledge details and self-handicapping strategies, can successfully use countermeasures by adjusting their statements so that they sound like truth tellers. We also examined whether the presence of an interpreter affect these results. Method: In both experiments, truth tellers discussed a trip they had made; lie tellers fabricated a story. Participants were of Lebanese, Mexican and South-Korean origin. Prior to the interview participants in Experiment 1 did or did not receive information about (i) the working of the Model Statement tool and (ii) three types of verbal detail: complications, common knowledge details and self-handicapping strategies. In Experiment 2 the Model Statement Pre-Information factor was replaced by the presence/absence of an interpreter. Results/Conclusions: We found no evidence that lie tellers adjusted their responses after being informed about the Model Statement and / or the types of detail we examined. (AU)
Antecedentes: Se analiza en dos experimentos si las personas que mienten, una vez han leído artículos sobre la entrevista estándar de obtención de la declaración y auto-depreciación sobre los problemas de los indicios verbales verbales, detalles de conocimiento común y las estrategias de autojustificación pueden utilizar eficazmente contramedidas para ajustar sus declaraciones de modo que parezca que dicen la verdad. También analizamos si influye en estos resultados la presencia de un intérprete. Método: En ambos experimentos, los sujetos que decían la verdad hablaban de un viaje que habían hecho, mientras que los que mentían se inventaban una historia. Los participantes eran de origen libanés, mexicano y surcoreano. Antes de la entrevista los participantes en el experimento 1 no recibían información sobre (i) el funcionamiento de la entrevista estándar de obtención de la declaración y (ii) sobre los tres tipos de detalles verbales: complicaciones, detalles del conocimiento común y estrategias de auto-depreciación. En el experimento 2 se sustituyó el factor información previa sobre la entrevista estándar de obtención de la declaración por la presencia/ausencia de un intérprete. Resultados/Conclusiones: Los resultados nos prestaron apoyo a que los que mienten ajusten sus respuestas tras ser informados sobre la entrevista estándar de obtención de la declaración o los tipos de detalles examinados. (AU)
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Humanos , Detecção de Mentiras , PsicologiaRESUMO
Background:Investigators often use maps in forensic interviews to verify a route that was taken by a suspect to obtain additional information, and to assess credibility.Method: We examined the effects of the level of map richness on the elicitation of information and cues to deceit. A total of 112 participants completed a mock secret mission and were asked to tell the truth (to a friendly agent) or to lie (to a hostile agent) about it in an interview. In phase 1 of the interview, all participants provided a verbal free recall of the mission. In phase 2, half of the participants were given a detailed map that included all street names and landmarks of the city where they completed the mission (zoomed in to 80%), and the other half were given a less detailed map that included the names of only major streets and landmarks (zoomed in to 60%). All participants were asked to verbally describe the mission and the route taken while sketching on the map. Results: Compared to lie tellers, truth tellers provided more location, action, temporal, and object details and complications in phase 1, and new person, location, action, and object details and complications in phase 2. Map richness did not have an effect on the amount of information elicited and had an equal effect on truth tellers and lie tellers. Conclusions: This initial experiment in this research area suggests that investigators do not have to worry about the exact level of map detailedness when introducing maps in interviews.
Antecedentes: Los investigadores utilizan a menudo mapas en las entrevistas forenses para verificar el camino seguido por un sospechoso para obtener más información y para valorar la credibilidad. Método: Analizamos los efectos del nivel de riqueza del mapa en la obtención de información e indicios de engaño. Un total de 112 participantes simularon participar en una misión secreta, pidiéndoseles que, en una entrevista, dijeran la verdad (a un agente amistoso) o mintieran (a un agente hostil) sobre la misión. En la fase 1 de la entrevista se recabó de los participantes un recuerdo libre de la misión y en la fase 2 se facilitó a la mitad un mapa detallado con los nombres de las calles y puntos de referencia de la ciudad en la que habían llevado a cabo la misión (ampliado hasta el 80%) y a la otra mitad se les dio un mapa menos detallado solo con los nombres de las calles y puntos de referencia principales (ampliado hasta el 60%). Se pidió a los participantes que describieran verbalmente la misión y el camino seguido al tiempo que la proyectaban en el mapa. Resultados: En comparación con los participantes instruidos para mentir, los instruidos para contar la verdad daban más detalles sobre ubicación, acciones, tiempo y objetos y complicaciones en la fase 1 y detalles nuevos sobre personas, ubicaciones, acciones y objetos y complicaciones en la fase 2. La riqueza del mapa no influía en el volumen de información producida y tenía el mismo efecto, tanto en los instruidos para contar la verdad como una mentira. Conclusiones: Este primer experimento en esta área de investigación sugiere que los investigadores no deben preocuparse por el nivel exacto de detalle del mapa cuando introduzcan estos en las entrevistas.
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Humanos , Ciências da Saúde , Psicologia Forense/instrumentação , Psicologia Forense/métodos , Detecção de Mentiras/psicologia , Entrevista Psicológica/métodosRESUMO
Cognitive Credibility Assessment (CCA) is a verbal lie detection tool consisting of several interview techniques. These techniques have been examined separately but never together. Reflecting the dynamic nature of CCA we combined several of the techniques (free recall followed by a model statement, followed by a reverse order instruction, and followed by a sketch instruction). We examined the new information provided after each stage of the interview and also compared the information provided in the initial recall with the information provided after the entire interview. A total of 47 truth tellers and 47 lie tellers went on a mission. Truth tellers were asked to report their mission truthfully, whereas lie tellers were requested to lie about several aspects of the mission. We measured the total units of information (total details) provided in the interview and the number of complications reported. The results indicate that the pre-registered hypothesis (Hypothesis 1) was supported for complications. Truth tellers reported more complications than lie tellers in each stage of the interview and the difference was more pronounced after the entire interview than after the free recall. As a conclusion, CCA was an effective lie detection method when complications were taken into account
La evaluación cognitiva de la credibilidad (ECC) es una herramienta verbal de detección de mentiras que incluye varias técnicas de entrevista. Dichas técnicas se han examinado por separado pero nunca juntas. Para reflejar el carácter dinámico de la ECC combinamos varias de las técnicas (recuerdo libre seguido de una declaración tipo, seguido de una instrucción de recuerdo en orden inverso, y de una instrucción para que hagan un sketch -esquema- durante la narración del evento). Analizamos la información nueva proporcionada tras cada etapa de la entrevista y también comparamos la información procedente del recuerdo inicial con la aportada por toda la entrevista. Un total de 47 sujetos que decían la verdad y 47 que mentían fueron enviados a una misión. A los participantes de la condición de testimonio verdadero se les pidió que informaran de su misión de modo veraz, mientras que los de la condición de mentira se les solicitó que mintieran sobre distintos aspectos de la misión. Se midió el total de unidades de información (detalles totales) de la entrevista y el número de complicaciones de las que se informaba. Los resultados mostraron que los participantes de la condición de verdad informaban de más detalles y complicaciones (hipótesis 1) en cada fase de la entrevista siendo las mayores diferencias tras la entrevista global que tras el recuerdo libre. En conclusión, la categoría complicaciones de la ECC es eficaz en la detección de la mentira
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Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Entrevista Psicológica/métodos , Valor Preditivo dos Testes , Revelação da Verdade , Detecção de Mentiras/psicologia , Cognição/classificação , Reprodutibilidade dos Testes , Rememoração Mental/classificação , Estudo de Prova de ConceitoRESUMO
We examined how much information British and Arab truth tellers and lie tellers volunteer in an initial free narrative. Based on cultural differences in communication styles we predicted that British interviewees would report more details and more complications than Arab interviewees (culture main effect). We further predicted that truth tellers would report more details and complications than lie tellers (veracity main effect), particularly in the British sample (Veracity × Culture interaction effect). A total of 78 British and 76 Israeli-Arab participants took part. The experiment was carried out at a British university and an Israeli university. Participants carried out a mission. Truth tellers were instructed to report the mission truthfully in a subsequent interview whereas lie tellers were asked to lie about certain aspects of the mission. The three hypotheses were supported for details, whereas for complications only the predicted veracity main effect occurred.
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BACKGROUND/AIMS: Human grading of digital images from diabetic retinopathy (DR) screening programmes represents a significant challenge, due to the increasing prevalence of diabetes. We evaluate the performance of an automated artificial intelligence (AI) algorithm to triage retinal images from the English Diabetic Eye Screening Programme (DESP) into test-positive/technical failure versus test-negative, using human grading following a standard national protocol as the reference standard. METHODS: Retinal images from 30 405 consecutive screening episodes from three English DESPs were manually graded following a standard national protocol and by an automated process with machine learning enabled software, EyeArt v2.1. Screening performance (sensitivity, specificity) and diagnostic accuracy (95% CIs) were determined using human grades as the reference standard. RESULTS: Sensitivity (95% CIs) of EyeArt was 95.7% (94.8% to 96.5%) for referable retinopathy (human graded ungradable, referable maculopathy, moderate-to-severe non-proliferative or proliferative). This comprises sensitivities of 98.3% (97.3% to 98.9%) for mild-to-moderate non-proliferative retinopathy with referable maculopathy, 100% (98.7%,100%) for moderate-to-severe non-proliferative retinopathy and 100% (97.9%,100%) for proliferative disease. EyeArt agreed with the human grade of no retinopathy (specificity) in 68% (67% to 69%), with a specificity of 54.0% (53.4% to 54.5%) when combined with non-referable retinopathy. CONCLUSION: The algorithm demonstrated safe levels of sensitivity for high-risk retinopathy in a real-world screening service, with specificity that could halve the workload for human graders. AI machine learning and deep learning algorithms such as this can provide clinically equivalent, rapid detection of retinopathy, particularly in settings where a trained workforce is unavailable or where large-scale and rapid results are needed.
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Algoritmos , Inteligência Artificial , Retinopatia Diabética/diagnóstico , Processamento de Imagem Assistida por Computador/métodos , Programas de Rastreamento/métodos , Retina/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Reprodutibilidade dos Testes , Estudos Retrospectivos , Adulto JovemRESUMO
Typically, truth-tellers report more detailed statements when interviewed immediately, compared to after delays (displaying forgetting), whereas liars report statements containing similar amounts of detail when interviewed immediately or after a delay (displaying a metacognitive error). Accordingly, the diagnostic utility of the 'richness-of-detail' cue is reduced after delays. We investigated if initial interviewing can facilitate lie-detection using the richness-of-detail cue in sub-optimal memorial conditions, that is, when (i) interviewing occurred after a three-week delay and (ii) truth-teller's attention during encoding was manipulated. Participants (n = 152) witnessed an interaction, that was meaningful to (and intentionally encoded by) liars (n = 50) and half of truth-tellers (n = 51), but meaningless (and incidentally encoded by) the remaining truth-tellers (n = 51). Participants were interviewed after three weeks. Half of the intentional liars and half of the intentional and incidental truth-tellers were also interviewed immediately (initial interview-present condition), whereas the remaining participants received no immediate interview (initial interview-absent condition). Results showed intentional and incidental truth-tellers reported after three weeks more detail in the initial interview-present (versus absent) condition, whereas intentional liars' statements were unaffected by initial interviewing condition. After three weeks, more intentional liars and intentional truth-tellers were correctly distinguished in the initial interview-present (versus absent) condition.
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Enganação , Rememoração Mental , Metacognição , HumanosRESUMO
In a countermeasures experiment, we examined to what extent liars who learn about the Model Statement tool and about the proportion of complications (complications/complications + common knowledge details + self-handicapping strategies) can successfully adjust their responses so that they sound like truth tellers. Truth tellers discussed a trip they had made; liars fabricated a story. Participants were of Lebanese, Mexican, and South-Korean origin. Prior to the interview they did or did not receive information about (I) the working of the Model statement and (II) three types of verbal detail: complications, common knowledge details and self-handicapping strategies. We found no evidence that liars sounded like truth tellers after being informed about the Model Statement and/or types of detail we examined. Actually, veracity differences were similar across experimental conditions, with truth tellers reporting more detail and more complications and obtaining a higher proportion of complications score than liars
En un experimento de contramedidas examinamos hasta qué punto los mentirosos que reciben información sobre la Declaración modelo y la proporción de complicaciones que presenta (complicaciones / complicaciones + detalles de conocimiento general + estrategias de autoobstaculización) pueden ajustar sus respuestas con éxito para que parezca que dicen la verdad. Los que dicen la verdad declararon sobre un viaje que habían hecho; los mentirosos inventaron una historia. Los participantes eran de origen libanés, mexicano y surcoreano. Antes de la entrevista habían recibido o no información sobre (I) el funcionamiento de la Declaración modelo y (II) tres tipos de detalles verbales: complicaciones, detalles de conocimiento general y estrategias de autoobstaculización. No encontramos evidencia de que los mentirosos se parecieran a los que dicen la verdad después de ser informados sobre la Declaración modelo y los tipos de detalle que examinamos. En realidad, las diferencias de veracidad fueron semejantes en todas las condiciones experimentales: los que decían la verdad informaron con mayor detalle y de más complicaciones y obtuvieron una mayor puntuación en la proporción de complicaciones que los mentirosos
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Psicologia Experimental/métodos , Detecção de Mentiras/psicologia , Revelação da Verdade , Coleta de Dados/classificação , Entrevistas como Assunto/estatística & dados numéricos , Processos Mentais/classificação , Estudantes/psicologiaRESUMO
The application of alibi witness scenarios to deception detection has been overlooked. Experiment 1 was a study of the verifiability approach in which truth-telling pairs completed a mission together, whereas in lying pairs one individual completed this mission alone and the other individual committed a mock theft. All pairs were instructed to convince the interviewer that they completed the mission together by writing individual statements on their own followed by a collective statement together as a pair. In the individual statements, truth-telling pairs provided more checkable details that demonstrated they completed the mission together than lying pairs, whereas lying pairs provided more uncheckable details than truth-telling pairs. The collective statements made truth-telling pairs provide significantly more checkable details that demonstrated they were together in comparison to the individual statements, whereas no effect was obtained for lying pairs. Receiver Operating Characteristic curves revealed high accuracy rates for discriminating between truths and lies using the verifiability approach across all statement types. Experiment 2 was a lie detection study whereby observers' abilities to discriminate between truths and lies using the verifiability approach were examined. This revealed that applying the verifiability approach to collective statements improved observers' ability to accurately detect deceit. We suggest that the verifiability approach could be used as a lie detection technique and that law enforcement policies should consider implementing collective interviewing.
Assuntos
Enganação , Aprendizagem por Discriminação/fisiologia , Detecção de Mentiras/psicologia , Adolescente , Adulto , Humanos , Masculino , Adulto JovemRESUMO
Truth tellers provide less detail in delayed than in immediate interviews (likely due to forgetting), whereas liars provide similar amounts of detail in immediate and delayed interviews (displaying a metacognitive stability bias effect). We examined whether liar's flawed metacognition after delays could be exploited by encouraging interviewees to provide more detail via a Model Statement. Truthful and deceptive participants were interviewed immediately (n = 78) or after a three-week delay (n = 78). Half the participants in each condition listened to a Model Statement before questioning. In the Immediate condition, truth tellers provided more details than liars. This pattern was unaffected by the Model Statement. In the Delayed condition, truth tellers and liars provided a similar amount of detail in the Model Statement-absent condition, whereas in the Model Statement-present condition, liars provided more details than truth tellers.
Assuntos
Estimulação Acústica/psicologia , Percepção Auditiva/fisiologia , Enganação , Revelação , Relações Interpessoais , Metacognição/fisiologia , Estimulação Acústica/métodos , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
Research examining how truth tellers' and liars' verbal behavior is attenuated as a function of delay is largely absent from the literature, despite its important applied value. We examined this factor across 2 studies in which we examined the effects of a hypothetical delay (Experiment 1) or actual delay (Experiment 2) on liars' accounts. In Experiment 1-an insurance claim interview setting-claimants either genuinely experienced a (staged) loss of a tablet device (n = 40) or pretended to have experienced the same loss (n = 40). Truth tellers were interviewed either immediately after the loss (n = 20) or 3 weeks after the loss (n = 20), whereas liars had to either pretend the loss occurred either immediately before (n = 20) or 3 weeks before (n = 20) the interview (i.e., hypothetical delay for liars). In Experiment 2-a Human Intelligence gathering setting-sources had to either lie (n = 50) or tell the truth (n = 50) about a secret video they had seen concerning the placing of a spy device. Half of the truth tellers and liars where interviewed immediately after watching the video (n = 50), and half where interviewed 3-weeks later (n = 50; i.e., real delay for liars). Across both experiments, truth tellers interviewed after a delay reported fewer details than truth tellers interviewed immediately after the to-be-remembered event. In both studies, liars failed to simulate this pattern of forgetting and reported similar amounts of detail when interviewed without or after a delay, demonstrating a stability bias in reporting. (PsycINFO Database Record
Assuntos
Enganação , Comportamento Verbal , Adolescente , Adulto , Feminino , Humanos , Entrevistas como Assunto , Maquiavelismo , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
We examined how the presence of an interpreter during an interview affects eliciting information and cues to deceit, while using a method that encourages interviewees to provide more detail (model statement, MS). A total of 199 Hispanic, Korean and Russian participants were interviewed either in their own native language without an interpreter, or through an interpreter. Interviewees either lied or told the truth about a trip they made during the last twelve months. Half of the participants listened to a MS at the beginning of the interview. The dependent variables were 'detail', 'complications', 'common knowledge details', 'self-handicapping strategies' and 'ratio of complications'. In the MS-absent condition, the interviews resulted in less detail when an interpreter was present than when an interpreter was absent. In the MS-present condition, the interviews resulted in a similar amount of detail in the interpreter present and absent conditions. Truthful statements included more complications and fewer common knowledge details and self-handicapping strategies than deceptive statements, and the ratio of complications was higher for truth tellers than liars. The MS strengthened these results, whereas an interpreter had no effect on these results.