1.
Bioorg Med Chem Lett
; 17(15): 4369-73, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17601734
RESUMO
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.
Assuntos
Resistência à Insulina , PPAR delta/agonistas , Transferência Ressonante de Energia de Fluorescência , Relação Estrutura-Atividade
2.
Bioorg Med Chem Lett
; 16(2): 297-301, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16275080
RESUMO
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.