Randomised clinical trial of extended depth of focus lenses for controlling myopia progression: Outcomes from SEED LVPEI Indian Myopia Study.

PURPOSE: To determine the efficacy of extended depth of focus (EDOF) contact lenses for controlling myopia progression in children through a 1-year randomised clinical trial. METHODS: A total of 104 children aged 7-15 years, with spherical equivalent refraction ≤-0.50 D, were randomly assigned to wear SEED 1 dayPure EDOF Mid contact lenses (n=48) or single vision spectacle lenses (n=56). Cycloplegic refraction with Shin-Nippon open field autorefractor and axial length with Lenstar LS 900 was determined at the baseline and 12-month visits. The compliance, visual discomfort and dryness questionnaires were administered during the final visit. RESULTS: Sixty-nine children (control: n=38; treatment: 31) completed the 12-month follow-up visit, with no difference in baseline characteristics between the groups. Mean (SEM) myopia progression in the 12th month was -0.48±0.07D in the control group and -0.20±0.08D in the treatment group. Mean axial elongation was 0.22±0.03 mm and 0.11±0.03 mm in the control and treatment groups, respectively. SEED 1 dayPure EDOF Mid contact lenses slowed myopia progression by 59% (-0.28D; p=0.01) based on spherical equivalent refraction and controlled axial length by 49% (0.11 mm; p=0.007) in comparison to single vision spectacle lenses. None of the participants reported any adverse effects. While most of the participants (82%) were comfortable with the contact lenses, 11% reported occasional dryness and 14% experienced mild fluctuations in visual acuity after immediate lens wear. CONCLUSION: Daily wear of SEED 1 dayPure EDOF Mid contact lenses in Indian children showed a significant effect in controlling myopia progression and axial elongation.

Myopia progression risk assessment score (MPRAS): a promising new tool for risk stratification.

Timely identification of individuals "at-risk" for myopia progression is the leading requisite for myopia practice as it aids in the decision of appropriate management. This study aimed to develop 'myopia progression risk assessment score' (MPRAS) based on multiple risk factors (10) to determine whether a myope is "at-risk" or "low-risk" for myopia progression. Two risk-score models (model-1: non-weightage, model-2: weightage) were developed. Ability of MPRAS to diagnose individual "at-risk" for myopia progression was compared against decision of five clinicians in 149 myopes, aged 6-29 years. Using model-1 (no-weightage), further 7 sub-models were created with varying number of risk factors in decreasing step-wise manner (1a: 10 factors to 1g: 4 factors). In random eye analysis for model-1, the highest Youden's J-index (0.63-0.65) led to the MPRAS cut-off score of 41.50-43.50 for 5 clinicians with a sensitivity ranging from 78 to 85% and specificity ranging from 79 to 87%. For this cut-off score, the mean area under the curve (AUC) between clinicians and the MPRAS model ranged from 0.89 to 0.90. Model-2 (weighted for few risk-factors) provided similar sensitivity, specificity, and AUC. Sub-model analysis revealed greater AUC with high sensitivity (89%) and specificity (94%) in model-1g that has 4 risk factors compared to other sub-models (1a-1f). All the MPRAS models showed good agreement with the clinician's decision in identifying individuals "at-risk" for myopia progression.

Do Anisometropic Eyes Have Steeper Retinas Than Their Isometropic Counterparts?

SIGNIFICANCE: Our findings suggest that retinal shapes of the eyes of anisometropes are not different from that of the eyes of isometropes with the same refractions. PURPOSE: We investigated ( a ) intereye differences in relative peripheral eye lengths between isometropes and anisometropes and ( b ) if the retinal shape is different between isometropic and anisometropic eyes with the same central refraction. METHODS: Central and peripheral eye lengths were determined along the horizontal meridian in 10° intervals out to ±30° using a noncontact biometer in 28 isometropes and 16 anisometropes. Retinal coordinates were estimated using these eye lengths and ray tracing. Retinal shape was determined in terms of vertex radius of curvature ( Rv ), asphericity ( Q ), and equivalent radius of curvature ( REq ). Linear regression was determined for the REq as functions of central refraction in a subset of isometropic and anisometropic eyes having the same refraction. RESULTS: The differences in relative peripheral eye lengths between the two eyes of anisometropes were significantly greater than for isometropes at ±30° eccentricities. Higher myopic eyes of anisometropes had smaller Rv , more negative Q , and smaller REq than the lower myopic eyes for both isometropes and anisometropes (mean ± standard error of the mean: Rv , 9.8 ± 0.5 vs. 11.7 ± 0.4 mm [ P = .002]; Q , -1.1 ± 0.2 vs. -0.5 ± 0.2 [ P = .03]; REq , 11.5 ± 0.3 vs. 12.4 ± 0.2 mm [ P = .01]). Intercepts and slopes of the linear regressions of REq in anisometropes and their isometropic counterparts with the same refraction were not significantly different from each other ( P > .05). CONCLUSIONS: Higher myopic eyes of anisometropes had similar retina shapes along the horizontal meridian to those of isometropic eyes with the same refraction.

Factors associated with reduced visual acuity in myopes with and without ocular pathologies after optical correction.

PURPOSE: Considering that a certain proportion of high myopes have reduced visual acuity even after full optical correction, this study aimed to investigate the association between various refractive error components (sphere, cylinder and axis orientation) and reduced visual acuity in individuals with low to high myopia with and without pathologic myopia lesions. METHODS: We analysed data from randomly selected eyes of 11,258 individuals with myopia (mean ± SD spherical equivalent (SE) -3.2 ± 2.9D; range: -0.5D to -21.5D). In total, 10,528 individuals had no pathologic myopia lesions. Sphere, cylinder and SE refraction were classified into mild, moderate and high categories. Astigmatism was defined as with-the-rule, against-the-rule or oblique based on the axis orientation. Reduced best-corrected visual acuity was defined as ≥0.18 logMAR. Logistic regression was performed to test factors associated with reduced visual acuity with and without pathologic myopia lesions. RESULT: Overall, 6.4% (N = 720/11,258) of myopes had reduced best-corrected visual acuity. High sphere (≤-6.0D; Odd ratios [OR]: 16.1; 95% CI: 2.1-126.5), high cylinder (<-2.0 DC; OR: 2.5; 95% CI: 1.8-3.4), against-the-rule (OR: 1.5; 95% CI: 1.1-2.0) and oblique astigmatism (OR: 1.6; 95% CI: 1.2-2.1) were significantly (p ≤ 0.008) associated with reduced visual acuity in the absence of pathologic myopia lesions. Both moderate SE and high myopic SE were also associated with reduced visual acuity. In the presence of pathologic myopia lesions, tessellated fundus (OR: 6.9; 95% CI: 3.5-14.1), chorioretinal atrophy (OR: 7.7; 95% CI: 2.6-19.9) and choroidal neovascularisation (OR: 37.4; 95% CI: 3.3-419.3) were significantly (p ≤ 0.003) associated with reduced visual acuity. CONCLUSION: Even after full optical correction, both refractive components and pathologic myopia lesions can independently cause reduced visual acuity, regardless of the degree of myopia.

Do myopes have deficits in peripheral flicker sensitivity?

Purpose: Signals from the peripheral retina are important for myopia development. Unlike temporal vision, deficits in peripheral spatial visual functions of myopes have been investigated previously. This study investigated temporal contrast thresholds in emmetropes and myopes at different retinal eccentricities.Methods: Forty-four young adults (mean age 23 ± 3 years) including 21 emmetropes (Spherical Equivalent (SE): +0.01 ± 0.30D) and 23 myopes (SE: -3.98 ± 2.41D) participated in this prospective study. Flicker modulation thresholds (FMT) were determined monocularly (right eye) for 15 Hz flicker stimulus at 0°, nasal (23°, 10°) and temporal (-23°, -10°) retinal eccentricities along the horizontal meridian. FMTs were measured psychophysically using 5-adaptive interleaved staircases and threshold was taken as the average of the last 6 reversals.Results: In both the groups (emmetropes and myopes), there was a naso-temporal asymmetry in FMTs with higher thresholds in the far temporal retina (Median; Interquartile range: 40.97%; 17.06) than the nasal retina (28.07%; 9.36) (p < 0.001). Flicker modulation thresholds were significantly higher in myopes (30.58%; 12.15) compared to emmetropes (26.77%; 7.74; p = 0.04) at far nasal retina (23°), while at other eccentricities there was no effect (p > 0.05). Further sub-analysis revealed only high myopes (34.48 %, 21.9) showed significantly higher FMT compared to emmetropes (26.77%; 7.74; p = 0.04).Conclusion: Greater FMTs were seen in high myopes than that of emmetropes in the nasal retina. Further studies exploring the structural aspects of the myopic eye with FMT would provide a better understanding of role of flicker sensitivity in myopiogenesis. (AU)

Do myopes have deficits in peripheral flicker sensitivity?

PURPOSE: Signals from the peripheral retina are important for myopia development. Unlike temporal vision, deficits in peripheral spatial visual functions of myopes have been investigated previously. This study investigated temporal contrast thresholds in emmetropes and myopes at different retinal eccentricities. METHODS: Forty-four young adults (mean age 23 ± 3 years) including 21 emmetropes (Spherical Equivalent (SE): +0.01 ± 0.30D) and 23 myopes (SE: -3.98 ± 2.41D) participated in this prospective study. Flicker modulation thresholds (FMT) were determined monocularly (right eye) for 15 Hz flicker stimulus at 0°, nasal (23°, 10°) and temporal (-23°, -10°) retinal eccentricities along the horizontal meridian. FMTs were measured psychophysically using 5-adaptive interleaved staircases and threshold was taken as the average of the last 6 reversals. RESULTS: In both the groups (emmetropes and myopes), there was a naso-temporal asymmetry in FMTs with higher thresholds in the far temporal retina (Median; Interquartile range: 40.97%; 17.06) than the nasal retina (28.07%; 9.36) (p < 0.001). Flicker modulation thresholds were significantly higher in myopes (30.58%; 12.15) compared to emmetropes (26.77%; 7.74; p = 0.04) at far nasal retina (23°), while at other eccentricities there was no effect (p > 0.05). Further sub-analysis revealed only high myopes (34.48 %, 21.9) showed significantly higher FMT compared to emmetropes (26.77%; 7.74; p = 0.04). CONCLUSION: Greater FMTs were seen in high myopes than that of emmetropes in the nasal retina. Further studies exploring the structural aspects of the myopic eye with FMT would provide a better understanding of role of flicker sensitivity in myopiogenesis.