RESUMO
6-RNH- and 6-R2NNH-pyrazine-2-carbothioamides 1--3, 5, 6, 9 and 14 were obtained from 2-cyano-6-chloropyrazine. In the in vitro screening the thioamides were active against Myc. tuber. H37Rv at the conc. range of 15.6--250 microgram/cm3. The most active thioamides 1 and 8, however, do not act in experimental tuberculosis in guinea pigs.
Assuntos
Pirazinas/uso terapêutico , Tuberculose/tratamento farmacológico , Aminas/uso terapêutico , Animais , Química Farmacêutica , Hidrazinas/uso terapêutico , Camundongos , Mycobacterium tuberculosis/efeitos dos fármacosAssuntos
Formiatos , Tiazóis , Antituberculosos/síntese química , Cloro , Indicadores e Reagentes , TionasAssuntos
Amidas , Pirazinas , Tioamidas , Aminas , Antituberculosos/síntese química , Fenômenos Químicos , Química , MetilaçãoRESUMO
By alcoholysis of 2-cyjano-6-chloropyrazine corresponding 6-alkoxypyrazine-2-imidoesters (1,6,11,16) were formed, which were then transformed in esters and amides of 6-alkoxypyrazine-2-carboxylic acids. Some of these compounds show a weak tuberculostatic activity.
Assuntos
Antituberculosos , Ácidos Carboxílicos , Pirazinas , Antituberculosos/síntese química , Antituberculosos/farmacologia , Ácidos Carboxílicos/síntese química , Ácidos Carboxílicos/farmacologia , Fenômenos Químicos , Química , Mycobacterium tuberculosis/efeitos dos fármacos , Pirazinas/síntese química , Pirazinas/farmacologiaRESUMO
In the reaction of 2-cyanomethylbenzmidazole and their 1- and 5-methyl derivatives with aromatic isocyanates and isothiocyanates, 23 N-arylamides resp. thioamides of benzimidazolyl-2-alpha-cyanoacetic acid were obtained. The structure of the newly compounds (Table 1) was confirmed by NMR and IR spectra. Some of these shown moderate tuberculostatic activity in vitro.
Assuntos
Benzimidazóis , Cianatos , Tiocianatos , Benzimidazóis/síntese química , Benzimidazóis/farmacologia , Fenômenos Químicos , Química , Espectroscopia de Ressonância Magnética , Mycobacterium tuberculosis/efeitos dos fármacos , Espectrofotometria InfravermelhoRESUMO
The nucleophilic exchange of chlorine atom in 2-chloro-3-cyanopyridine with morpholine, piperidine and pyrrolidine was carried out. Acids, amides, thioamides, esters and hydrazides were derived from the obtained compounds (Fig. 1). Some of these compounds showed only moderate tuberculostatic activity.
Assuntos
Ácidos Nicotínicos/síntese química , Fenômenos Químicos , Físico-Química , Métodos , Mycobacterium tuberculosis/efeitos dos fármacos , Ácidos Nicotínicos/farmacologiaRESUMO
Position of CH2CN group in the benzimidazole system determines the activity of hydrogen atoms of CH2 group in condensation reactions. Some of the obtained compounds show high tuberculostatic activity.
Assuntos
Aldeídos , Benzimidazóis , Cetonas , Compostos Nitrosos , Antituberculosos/síntese química , Fenômenos Químicos , Química , Indicadores e Reagentes , NitrilasRESUMO
The typing of Nocardia pellegrini with different Nocardia-phages was studied. The investigation included 25 Nocardia pellegrini strains, 19 strains of different Nocardia species and also strains of different species of mycobacteria. It could be stated that phages typical for Nocardia pellegrini were also active against other fast fragmentating Nocardia species, such as Nocardia corallina or Nocardia rubra. However, they did not attack Nocardia asteroides or strains of mycobacteria. Phages typical for mycobacteria or for Nocardia asteroides did not lysate the fast fragmentating nocardia (Table 1 and 2). Mutants of one Nocardia pellegrini phage could be isolated which showed a broader host range than the parent phage (Table 1 and 2). Some lysogenic strains of Nocardia pellegrini with a changed phage sensitivity could be isolated after action of the phages (Table 3). The taxonomical position of Nocardia pellegrini and Nocardia rubra is discussed.