Lipid-based formulations to increase cannabidiol bioavailability: In vitro digestion tests, pre-clinical assessment and clinical trial.

Herein, medium-chain triglycerides (MCT), glyceryl monolinoleate (GML), and a self-emulsifying drug delivery system (SEDDS) for cannabidiol (CBD) delivery were compared using in vitro and in vivo (mouse and human) studies. In vitro digestion tests showed that SEDDS yielded the highest CBD recovery in the aqueous phase (86 ± 2%), followed by GML (13 ± 2%) and MCT (5.6% ± 0.8%). In vivo tests (mouse) revealed that SEDDS promoted the highest CBD exposure, exhibiting an area under the plasma concentration-time curve (AUC0-6h) 1.48 times greater than GML and 3.97 times greater than that of the MCT formulation. A single-dose, open-label, crossover study performed in 11 volunteers showed that SEDDS increased CBD AUC0-12h by 1.12 and 1.48 times in relation to GML and MCT, respectively. The in vitro-in vivo correlation was r2 0.75 for mice and r2 0.66 for humans. The AUC correlation between mice and humans was 0.98. Collectively, these results indicate that the lipid profile substantially influences CBD delivery and highlights the potential of the SEDDS and GML formulations as candidate solutions for increasing CBD AUC and bioavailability.

The effects of resistance training on explosive strength indicators in adolescent basketball players.

The purpose of this study was to assess the effects of a lower- and upper-body 10-week in-season resistance training program on explosive strength development in young basketball players. Twenty-five adolescent male athletes, aged 14-15 years old, were randomly assigned to an experimental group (EG; n = 15) and a control group (CG; n = 10). The subjects were assessed at baseline and after training for squat jump (SJ), countermovement jump (CMJ), Abalakov test, drop jump, and seated medicine ball throw (MBT). The EG showed significant increases (p < 0.05) in all the variable scores. Conversely, the CG significantly decreased (p < 0.05) in SJ, CMJ, and Abalakov test scores and significantly increased in the results of MBT test (p < 0.05). The groups were similar on pretest, but significant differences (p < 0.05) occurred on posttest in all the variables. The results of this study show that a 10-week in-season resistance training program with moderate volume and intensity loads increased vertical jump and MBT performance in adolescent male basketball players. Coaches should know that such a short resistance training program specifically designed for young basketball players induce increased explosivity levels, which are essential to a better basketball performance, with no extra overload on adolescents' skeletal muscle development.

A new genus of dipnoiformes from the Cretaceous of Brazil.

The Alcântara Formation, an important stratigraphic unit from the early Cenomanian of Brazil, was deposited under transitional (estuarine) conditions, and its fossil record includes fragmentary remains of plants, fishes, crocodylomorphs, pterosaurs and dinosaurs, with a noteworthy diversity of dipnoiformes tooth plates. The dipnoiformes material reported here comprises a new taxon, Equinoxiodus alcantarensis, gen. et sp. nov. Most of the identified morphotypes of continental vertebrates collected in the Alcântara Formation are similar to chronocorrelative faunas from Northern Africa, but this new genus of Dipnoiformes indicates some degree of paleogeographic isolation and endemism. This was probably caused by the widening of the equatorial Atlantic Ocean during the early Cenomanian, which may have selectively affected some species.

A new genus of dipnoiformes from the Cretaceous of Brazil

The Alcântara Formation, an important stratigraphic unit from the early Cenomanian of Brazil, was deposited under transitional (estuarine) conditions, and its fossil record includes fragmentary remains of plants, fishes, crocodylomorphs, pterosaurs and dinosaurs, with a noteworthy diversity of dipnoiformes tooth plates. The dipnoiformes material reported here comprises a new taxon, Equinoxiodus alcantarensis, gen. et sp. nov. Most of the identified morphotypes of continental vertebrates collected in the Alcântara Formation are similar to chronocorrelative faunas from Northern Africa, but this new genus of Dipnoiformes indicates some degree of paleogeographic isolation and endemism. This was probably caused by the widening of the equatorial Atlantic Ocean during the early Cenomanian, which may have selectively affected some species.

A Formação Alcântara, uma importante unidade estratigráfica do início do Cenomaniano no Brasil, foi depositada sob condições transicionais (estuarinas), e o seu registro fóssil inclui restos fragmentários de vegetais, peixes, crocodilomorfos, pterossauros e dinossauros, com uma notável diversidade de placas dentárias de dipnoiformes. O material de dipnoiformes aqui reportado compreende um novo taxon, Equinoxiodus alcantarensis gen. et sp. nov. A maioria dos morfótipos de vertebrados continentais coletados na Formação Alcântara são similares a faunas cronocorrelatas do norte da África, mas este novo gênero de Dipnoiformes indica algum grau de isolamento paleogeográfico e endemismo, provavelmente causado pelo alargamento do Oceano Atlântico equatorial no início do Cenomaniano, que pode ter afetado, de forma seletiva, algumas espécies.

The effects of plyometric training followed by detraining and reduced training periods on explosive strength in adolescent male basketball players.

The aims of this study were to determine the effects of (a) plyometric training on explosive strength indicators in adolescent male basketball players and (b) detraining and reduced training on previously achieved explosive strength gains. Two groups were formed: an experimental and a control group. The former was submitted to a 10-week in-season plyometric training program, twice weekly, along with regular basketball practice. Simultaneously, the control group participated in regular basketball practice only. At the end of this period, the experimental group was subdivided into 2 groups: a reduced training group and a detraining group. All participants were assessed on squat jump, countermovement jump, Abalakov test, depth jump, mechanical power, and medicine ball throw at the beginning and at the end of the 10-week in-season plyometric training and on weeks 4, 8, 12, and 16 of the in-season detraining and reduced training periods. In the first phase of the study, the experimental group significantly increased all the assessed indicators (p < 0.05). In the following phase and in general all the groups maintained the previously achieved results. In conclusion, plyometric training showed positive effects on upper- and lower-body explosive strength in adolescent male basketball players. Moreover, we can state that both detraining and a reduced training program indistinctly contribute to maintenance of strength levels. These results highlight the unique power that basketball-specific training seems to have on the sustainability and maintenance of sport performance.

Effects of reduced training and detraining on upper and lower body explosive strength in adolescent male basketball players.

The purpose of this study was to assess and compare the effects of detraining and of a reduced training program on upper- and lower-body explosive strength in adolescent male basketball players. To study this, 15 subjects, aged 14 to 15 years old, were randomly assigned to 1 of the 2 following groups: reduced training (RT; n = 8) and detraining (DTR; n = 7). The participants were assessed on squat jump (SJ), countermovement jump (CMJ), Abalakov test (ABA), depth jump (DJ), mechanical power (MP), and medicine ball throw (MBT) after a 10-week in-season complex training program (T0) and at the end of 4 (T4), 8 (T8), 12 (T12), and 16 (T16) weeks of detraining and of the reduced training periods. Both groups showed maintenance of explosive strength values and statistical similarity between them whatever the moment of evaluation. In conclusion, 16 weeks of detraining or of reduced training allow for the maintenance of the gains previously achieved by the application of a 10-week in-season complex training program. However, the lack of differences between detraining and reduced training leads to the conclusion that regular basketball practice can sustain by itself the previously achieved explosive strength gains, considering its mainly explosive characteristics.

Scanning tunneling spectroscopy in the superconducting state and vortex cores of the beta-pyrochlore KOs2O6.

We performed the first scanning tunneling spectroscopy measurements on the pyrochlore superconductor KOs2O6 (T(c)=9.6 K) in both zero magnetic field and the vortex state at several temperatures above 1.95 K. This material presents atomically flat surfaces, yielding spatially homogeneous spectra which reveal fully gapped superconductivity with a gap anisotropy of 30%. Measurements performed at fields of 2 and 6 T display a hexagonal Abrikosov flux line lattice. From the shape of the vortex cores, we extract a coherence length of 31-40 A, in agreement with the value derived from the upper critical field H(c2). We observe a reduction in size of the vortex cores (and hence the coherence length) with increasing field which is consistent with the unexpectedly high and unsaturated upper critical field reported.

Effects of complex training on explosive strength in adolescent male basketball players.

The purpose of this study was to evaluate the effects of a complex training program, a combined practice of weight training and plyometrics, on explosive strength development of young basketball players. Twenty-five young male athletes, aged 14-15 years old, were assessed using squat jump (SJ), countermovement jump (CMJ), Abalakov test (ABA), depth jump (DJ), mechanical power (MP), and medicine ball throw (MBT), before and after a 10-week in-season training program. Both the control group (CG; n = 10) and the experimental group (EG; n = 15) kept up their regular sports practice; additionally, the EG performed 2 sessions per week of a complex training program. The EG significantly improved in the SJ, CMJ, ABA, and MBT values (p < 0.05). The CG significantly decreased the values (p < 0.05) of CMJ, ABA, and MP, while significantly increasing the MBT values (p < 0.05). Our results support the use of complex training to improve the upper and lower body explosivity levels in young basketball players. In conclusion, this study showed that more strength conditioning is needed during the sport practice season. Furthermore, we also conclude that complex training is a useful working tool for coaches, innovative in this strength-training domain, equally contributing to a better time-efficient training.