1.
J Cell Biol
; 221(5)2022 05 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35442398
RESUMO
Epithelial cell morphology is essential for cellular homeostasis, but the mechanisms by which cell shape is established remain unclear. In this study, Marivin et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111002) identify DAPLE as a linker between polarity complexes and the actomyosin network at apical junctions. By recruiting CD2P and activating Gαßγ-mediated RhoA signaling, DAPLE ensures proper cell shape and function.